CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027324
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 1-alpha 
Protein Synonyms/Alias
  
Gene Name
 PF13_0304, PF13_0305 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
30TTGHIIYKLGGIDRRacetylation[1]
96VIDAPGHKDFIKNMIacetylation[1]
159VNKMDTVKYSEDRYEacetylation[1]
169EDRYEEIKKEVKDYLacetylation[1]
282CKSVEMHKEVLEEARacetylation[1]
299DNIGFNVKNVSVKEIacetylation[1]
304NVKNVSVKEIKRGYVacetylation[1]
357HTSHISCKFLNIDSKacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 443 AA 
Protein Sequence
MGKEKTHINL VVIGHVDSGK STTTGHIIYK LGGIDRRTIE KFEKESAEMG KGSFKYAWVL 60
DKLKAERERG ITIDIALWKF ETPRYFFTVI DAPGHKDFIK NMITGTSQAD VALLVVPAEV 120
GGFEGAFSKE GQTKEHALLA FTLGVKQIVV GVNKMDTVKY SEDRYEEIKK EVKDYLKKVG 180
YQADKVDFIP ISGFEGDNLI EKSDKTPWYK GRTLIEALDT MEPPKRPYDK PLRIPLQGVY 240
KIGGIGTVPV GRVETGILKA GMVLNFAPSA VVSECKSVEM HKEVLEEARP GDNIGFNVKN 300
VSVKEIKRGY VASDTKNEPA KGCSKFTAQV IILNHPGEIK NGYTPVLDCH TSHISCKFLN 360
IDSKIDKRSG KVVEENPKAI KSGDSALVSL EPKKPMVVET FTEYPPLGRF AIRDMRQTIA 420
VGIIKSVEKK EPGAVTAKAP AKK 443 
Gene Ontology
 GO:0005853; C:eukaryotic translation elongation factor 1 complex; ISS:GeneDB_Pfalciparum.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.