CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vacuolar protein sorting-associated protein 16 homolog 
Protein Synonyms/Alias
  
Gene Name
 VPS16 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16PHQKESQKADEYLREubiquitination[1, 2, 3]
51EHQPDMQKSLLRVGLubiquitination[2]
178LAHWACYKVQQKDVSubiquitination[2]
182ACYKVQQKDVSDEDVubiquitination[1, 2, 3]
196VARAINQKLGDTPGVubiquitination[1, 2, 4, 5, 6]
223GRTELAIKLLEYEPRubiquitination[1, 2, 3, 6]
240EQVPLLLKMKRSKLAubiquitination[2]
303HQELETLKDLYNQDDubiquitination[2]
346TAADAFYKAKNEFAAubiquitination[2, 5, 6]
348ADAFYKAKNEFAAKAubiquitination[2]
354AKNEFAAKATEDQMRubiquitination[1, 2]
431EDWEELEKFSKSKKSubiquitination[2]
436LEKFSKSKKSPIGYLubiquitination[2]
470SRVGPEQKVKALLLVubiquitination[2]
514TDGATADKIQRARAQubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MMPWLWTAPH QKESQKADEY LREIQELGQL TQAVQQCIEA AGHEHQPDMQ KSLLRVGLDG 60
RAGEGGAGRG WDGQQGSSLL SPSGSSQAAS FGKCFLDRFP PDSFVHMCQD LRVLNAVRDY 120
HIGIPLTYSQ YKQLTIQVLL DRLVLRRLYP LAIQICEYLR LPEVQGVSRI LAHWACYKVQ 180
QKDVSDEDVA RAINQKLGDT PGVSYSDIAA RAYGCGRTEL AIKLLEYEPR SGEQVPLLLK 240
MKRSKLALSK AIESGDTDLV FTVLLHLKNE LNRGDFFMTL RNQPMALSLY RQFCKHQELE 300
TLKDLYNQDD NHQELGSFHI RASYAAEERI EGRVAALQTA ADAFYKAKNE FAAKATEDQM 360
RLLRLQRRLE DELGGQFLDL SLHDTVTTLI LGGHNKRAEQ LARDFRIPDK RLWWLKLTAL 420
ADLEDWEELE KFSKSKKSPI GYLPFVEICM KQHNKYEAKK YASRVGPEQK VKALLLVGDV 480
AQAADVAIEH RNEAELSLVL SHCTGATDGA TADKIQRARA QAQKK 525 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR016534; VPS16.
 IPR006925; Vps16_C.
 IPR006926; Vps16_N. 
Pfam
 PF04840; Vps16_C
 PF04841; Vps16_N 
SMART
  
PROSITE
  
PRINTS