CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinase suppressor of Ras 2 
Protein Synonyms/Alias
  
Gene Name
 KSR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
894EERPTFTKLMDMLEKubiquitination[1, 2, 3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 921 AA 
Protein Sequence
MIDLSISNLE GLRTKCATSN DLTQKEIRTL ESKLVKYFSR QLSCKKKVAL QERNAELDGF 60
PQLRHWFRIV DVRKEVLEEI SPGQLSLEDL LEMTDEQVCE TVEKYGANRE ECARLNASLS 120
CLRNVHMSGG NLSKQDWTIQ WPTTETGKEN NPVCPPEPTP WIRTHLSQSP RVPSKCVQHY 180
CHTSPTPGAP VYTHVDRLTV DAYPGLCPPP PLESGHRSLP PSPRQRHAVR TPPRTPNIVT 240
TVTPPGTPPM RKKNKLKPPG TPPPSSRKLI HLIPGFTALH RSKSHEFQLG HRVDEAHTPK 300
AKKKSKPLNL KIHSSVGSCE NIPSQQRSPL LSERSLRSFF VGHAPFLPST PPVHTEANFS 360
ANTLSVPRWS PQIPRRDLGN SIKHRFSTKY WMSQTCTVCG KGMLFGLKCK NCKLKCHNKC 420
TKEAPPCHLL IIHRGDPARL VRTESVPCDI NNPLRKPPRY SDLHISQTLP KTNKINKDHI 480
PVPYQPDSSS NPSSTTSSTP SSPAPPLPPS ATPPSPLHPS PQCTRQQKNF NLPASHYYKY 540
KQQFIFPDVV PVPETPTRAP QVILHPVTSN PILEGNPLLQ IEVEPTSENE EVHDEAEESE 600
DDFEEMNLSL LSARSFPRKA SQTSIFLQEW DIPFEQLEIG ELIGKGRFGQ VYHGRWHGEV 660
AIRLIDIERD NEDQLKAFKR EVMAYRQTRH ENVVLFMGAC MSPPHLAIIT SLCKGRTLYS 720
VVRDAKIVLD VNKTRQIAQE IVKGMGYLHA KGILHKDLKS KNVFYDNGKV VITDFGLFSI 780
SGVLQAGRRE DKLRIQNGWL CHLAPEIIRQ LSPDTEEDKL PFSKHSDVFA LGTIWYELHA 840
REWPFKTQPA EAIIWQMGTG MKPNLSQIGM GKEISDILLF CWAFEQEERP TFTKLMDMLE 900
KLPKRNRRLS HPGHFWKSAE L 921 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0019722; P:calcium-mediated signaling; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR025561; KSR_SAM-like_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF13543; KSR1-SAM
 PF07714; Pkinase_Tyr 
SMART
 SM00109; C1 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS