CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor corepressor 1 
Protein Synonyms/Alias
  
Gene Name
 Ncor1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
396SEQENNEKQMRQLSVubiquitination[1]
1280EGAITKGKPYDGITTacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2386 AA 
Protein Sequence
MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP STRHQQEFAV PDYRSSHIEV SQASQLLQQQ 60
QQQQQLRRRP SLLSEFHPGS DRPQERRTGY EQFHSGPSPV DHDSLESKRP RLEPVSDAHF 120
QRVSAAVLPL VHSLPEGLRS SADAKKDSAF GSKHEAPSSP LAGQPCGDDQ NASPSKLSKE 180
ELIQSMDRVD REIAKVEQQI LKLKKKQQQL EEEAAKPPEP EKPVSPPPVE QKHRSIVQII 240
YDENRKKAEE AHKIFEGLGP KVELPLYNQP SDTKVYHENI KTNQVMRKKL ILFFKRRNHA 300
RKQREQKICQ RYDQLMEAWE KKVDRIENNP RRKAKESKTR EYYEKQFPEI RKQREQQERF 360
QRVGQRGAGL SATIARSEHE ISEIIDGLSE QENNEKQMRQ LSVIPPMMFD AEQRRVKFIN 420
MNGLMEDPMK VYKDRQFMNV WTDHEKEIFK DKFIQHPKNF GLIASYLERK SVPDCVLYYY 480
LTKKNENYKA LVRRNYGKRR GRNQQIARPS QEEKVEEKEE DKAEKTEKKE EEKKDDEEKD 540
DKEDSKETTK EKDRTEATAE EPEEREQVTP RGRKTANSQG RRKGRVTRSM TSEAAAANAA 600
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA 660
QCKNFYFNYK RRHNLDNLLQ QHKQKVSRAV VASRKPREER DVSQCESVAS TVSAQEDEDI 720
EASNEEENPE DSEAVPTTKP AERESVEAQV TDSASAETAE PMDVDHEECG AEGSSVLDPP 780
APTKADSVDP EMQVPENTAS KGEGDAKERD LESTSEKTEA RDEDVVVAEQ IERPEPQSDD 840
DSSATCSADE GVDGEPERQR VFPMDAKPSL LTPPGSILIS SPIKPNPLDL PQLQHRAAVI 900
PPMVSCTPCN IPIGTPVSGY ALYQRHIKAM HESALLEEQR QRQEQVDLEC RSSTSPCSTS 960
KSPNREWEVL QPAPHQVITN LPEGVRLPTT RPTRPPPPLI PSSKTTVASE KPSFIMGGSI 1020
SQGTPGTYLS SHNQAYPQEA PKPSVGSISL GLPRQQESTK AAPLTYIKQE EFSPRSQNSQ 1080
PEGLLVRAQH EGTAGAVQEG SITRGTPASK ISVETISSLR GSITQGTPAL PQAGIPTEAL 1140
VKGPVSRMPI EESSPEKVRE EAASKGHVIY EGKSGHILSY DNIKNAREGT RSPRTAHEMS 1200
LKRSYEAVEG SIKQGLICRA LPRGSPHSDL KERTVLSGSI MQGTPRATAE SFEDGLKYPK 1260
QIKRESPPIR AFEGAITKGK PYDGITTIKE MGRSIHEIPR QDILTQESRK TPEVVQSTRP 1320
IIEGSISQGT PIKFDNNSGQ SAIKHNVKSL ITGPSKLPRG MLEIVPENIK VVERGKYEDV 1380
KAGEPVRARH TSVVSSGPSV LRSTLHEAPK AQLSPGLYDD SSARRTPVSY QNTISRGSPM 1440
MNRTSDVSSS KSASHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRSSAAGEVY 1500
RSHLPTHLDP AMPFHRALDP AAAAYLLQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS 1560
QQMQVNLRPD VTRGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHAGGT STPPMDRITY 1620
IPGTQVTFPP RPYNAASLSP GHPTHLAAAA SAERERERER EKERERERER ERERERERIA 1680
AAPADLYLRP GSEQPGRPGS HGYVRSPSPS VRTQETILQQ RPSVFQGTNG TSVITPLDPT 1740
AQLRIMPLPS GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE 1800
ENLRSRSAAV SEQQQLEQKN LEVEKRSVQC VCTSSALPSG KAQPHASVVY SEAGKDKGPP 1860
PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETAS 1920
DAIEVISPAS SPAPPQEKPQ AYQPDMVKAN QAENESTRQY EGPLHHYRSQ QESPSPQQQP 1980
PLPPSSQSEG MGQVPRTHRL ITLADHICQI ITQDFARNQV PSQPSTSTFQ TSPSALSSTP 2040
VRTKTSSRYS PESQSQTVLH PRPGPRVSPE NLVDKSRGRP GKSPERSHIP SEPYEPISPP 2100
QGPAVHEKQD SMLLLSQRGV DPAEQRSDSR SPGSISYLPS FFTKLESTSP MVKSKKQEIF 2160
RKLNSSGGGD SDMAAAQPGT EIFNLPAVTT SGAVSSRSHS FADPASNLGL EDIIRKALMG 2220
SFDDKVEDHG VVMSHPVGIM PGSASTSVVT SSEARRDEGE PSPHAGVCKP KLINKSNSRK 2280
SKSPIPGQSY LGTERPSSVS SVHSEGDYHR QTPGWAWEDR PSSTGSTQFP YNPLTIRMLS 2340
STPPTQIACA PSAITQAAPH QQNRIWEREP APLLSAQYET LSDSDD 2386 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0017053; C:transcriptional repressor complex; IPI:MGI.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0035033; F:histone deacetylase regulator activity; IDA:MGI.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0046966; F:thyroid hormone receptor binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IGI:MGI.
 GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0032922; P:circadian regulation of gene expression; IGI:MGI.
 GO:0060318; P:definitive erythrocyte differentiation; IMP:MGI.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IGI:MGI.
 GO:0021794; P:thalamus development; IMP:MGI. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS