CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039216
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 
Protein Synonyms/Alias
  
Gene Name
 Plcb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
72SRDAFLEKAYTKLKLacetylation[1]
76FLEKAYTKLKLQVTPacetylation[1]
90PEGRIPLKNIYRLFSacetylation[1]
383LMYKILVKNKKKSHKacetylation[1]
609SGQFLSDKKVGTYVEacetylation[1]
673AAYEEGGKFIGHRILacetylation[1]
757LEDEEEVKKEADPGEubiquitination[2]
849KKHYKEMKDLVKRHHacetylation[1]
929KLIDLKDKQQQQLLNubiquitination[2]
946QEQYYSEKYQKREHIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 966 AA 
Protein Sequence
DPKLRELLDV GNIGHLEQRM ITVVYGPDLV NISHLNLVAF QEEVAKEWTN EVFSLATNLL 60
AQNMSRDAFL EKAYTKLKLQ VTPEGRIPLK NIYRLFSADR KRVETALEAC SLPSSRNDSI 120
PQEDFTPDVY RVFLNNLCPR PEIDNIFSEF GAKSKPYLTV DQMMDFINLK QRDPRLNEIL 180
YPPLKQEQVQ VLIEKYEPNS SLAKKGQMSV DGFMRYLSGE ENGVVSPEKL DLNEDMSQPL 240
SHYFINSSHN TYLTAGQLAG NSSVEMYRQV LLSGCRCVEL DCWKGRTAEE EPVITHGFTM 300
TTEISFKEVI EAIAECAFKT SPFPILLSFE NHVDSPKQQA KMAEYCRLIF GDALLMEPLE 360
KYPLESGVPL PSPMDLMYKI LVKNKKKSHK SSEGSGKKKL SEQASNTYSD SSSVFEPSSP 420
GAGEADTESD DDDDDDDCKK SSMDEGTAGS EAMATEEMSN LVNYIQPVKF ESFETSKKRN 480
KSFEMSSFVE TKGLEQLTKS PVEFVEYNKM QLSRIYPKGT RVDSSNYMPQ LFWNAGCQMV 540
ALNFQTVDLA MQINMGMYEY NGKSGYRLKP EFMRRPDKHF DPFTEGIVDG IVANTLSVKI 600
ISGQFLSDKK VGTYVEVDMF GLPVDTRRKA FKTKTSQGNA VNPVWEEEPI VFKKVVLPSL 660
ACLRIAAYEE GGKFIGHRIL PVQAIRPGYH YICLRNERNQ PLMLPAVFVY IEVKDYVPDT 720
YADVIEALSN PIRYVNLMEQ RAKQLAALTL EDEEEVKKEA DPGETSSEAP SETRTTPAEN 780
GVNHTATLAP KPPSQAPHSQ PAPGSVKAPA KTEDLIQSVL TEVEAQTIEE LKQQKSFVKL 840
QKKHYKEMKD LVKRHHKKTT ELIKEHTTKY NEIQNDYLRR RAALEKSAKK DSKKKSEPSS 900
PDHGSSAIEQ DLAALDAEMT QKLIDLKDKQ QQQLLNLRQE QYYSEKYQKR EHIKLVSQKL 960
PGSAEE 966 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0016042; P:lipid catabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR016280; PLC-beta.
 IPR014815; PLC-beta_C.
 IPR009535; PLC-beta_CS.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 
Pfam
 PF00168; C2
 PF06631; DUF1154
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y
 PF08703; PLC-beta_C 
SMART
 SM00239; C2
 SM00148; PLCXc
 SM00149; PLCYc 
PROSITE
 PS50004; C2
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 
PRINTS
 PR00390; PHPHLIPASEC.