CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024644
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 UFM1-protein ligase 1 
Protein Synonyms/Alias
  
Gene Name
 Ufl1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
241VVGGRQDKAVFVPDIacetylation[1]
570DTQTALTKHLLKTVCacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1. The function of ufmylation is unknown (By similarity). May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (By similarity). 
Sequence Annotation
 REGION 1 212 Required for E3 UFM1-protein ligase
 MOD_RES 458 458 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Endoplasmic reticulum; Ligase; Phosphoprotein; Reference proteome; Tumor suppressor; Ubl conjugation; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 793 AA 
Protein Sequence
MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIENRVGDI IKSEKHVQMV LGQLVDENYL 120
DRLSEEVNDK LQESGQVTVS ELCKTYDLPG DFLTQALTQR LGRIINGHLD LDNRGVIFTE 180
AFVARHKARI RGLFSAITRP TAVNSLVSKY GFQEQLLYSV LEELVSTGRL RGTVVGGRQD 240
KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VNYIKKRYKN TPLLFLKATC 300
VGQGLVDQVE ASVEEAISSG TWVDVSPLLP SSLSVEDAAM LLQQVMRPFG KHASATVFSD 360
TVVVSEKFIN DCTKLFSERM HQKAEKEMKN NPVHLITEED LKQISILESV NTNKKDKKDE 420
RRKKATEGSG SVRGGGGGNA REYKIKKVKK KGRKDEDSDD ESQSSHAGKK KPDITFMFQD 480
EIEGCLRKHI PDAPEEFISE LAEHLIKPLN KMYLEVVRSV FMSSTSASGT GRKRTIKDLQ 540
EEVSNLYNNI RLFEKGMKYF ADDTQTALTK HLLKTVCTDI TNLMFNFLAS DLMMAVEDPA 600
TITSDMRKKI LSKLTEETKV ALTKLHNSLN EKSIEDFLSC LDSATEACDI MVKKGDKKRE 660
RQILFQHRQA LADQLKVTED PALILHLTSV LLFQFSTHSM LHAPGRCVPQ IIAFLHNKIP 720
EDQHTLLVKY QGLVVKQLVS QNKKSGQGED PSSDDLDKEQ HDVTNTTRKE LQELSLSIKD 780
LVLKPRKSSV TEE 793 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0071568; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
 GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
 GO:0071569; P:protein ufmylation; ISS:UniProtKB. 
Interpro
 IPR018611; E3_UFM1_ligase_1. 
Pfam
 PF09743; DUF2042 
SMART
  
PROSITE
  
PRINTS