UniProt Accession

 IRAK2_HUMAN; O43187; B4DQZ6; Q08AG6; Q5K546 

Genbank Protein ID

 AJ496794; AK299033; BC125184; AF026273 

Genbank Nucleotide ID

 CAD43180.3; BAG61108.1; AAI25185.1; AAB87669.1 

Protein Name

 Interleukin-1 receptor-associated kinase-like 2 

Protein Synonyms/Alias

 IRAK-2 

Gene Name

 IRAK2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
425	NRSPVYLKDLLLSDI	ubiquitination	[1]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. 

Sequence Annotation

 DOMAIN 13 94 Death.
 DOMAIN 210 489 Protein kinase.
 NP_BIND 216 224 ATP (By similarity).
 NP_BIND 337 340 ATP (By similarity).
 BINDING 237 237 ATP (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Nucleotide-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 625 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0000187; P:activation of MAPK activity; TAS:Reactome.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; TAS:ProtInc.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.
 GO:0007254; P:JNK cascade; TAS:Reactome.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
 GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
 GO:0006468; P:protein phosphorylation; TAS:ProtInc.
 GO:0001959; P:regulation of cytokine-mediated signaling pathway; IMP:BHF-UCL.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 

Pfam

 PF00531; Death
 PF00069; Pkinase 

SMART

  

PROSITE

 PS50017; DEATH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS