UniProt Accession

 AGT2_HUMAN; Q9BYV1; Q53FB4; Q53FY7; Q53G03; Q5W7Q1 

Genbank Protein ID

 AJ292204; AB193309; AK223128; AK223144; AK223375 

Genbank Nucleotide ID

 CAC24841.1; BAD66662.1; BAD96848.1; BAD97095.1 

Protein Name

 Alanine--glyoxylate aminotransferase 2, mitochondrial 

Protein Synonyms/Alias

 AGT 2; (R)-3-amino-2-methylpropionate--pyruvate transaminase; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT 

Gene Name

 AGXT2 

Gene Synonyms/Alias

 AGT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	KVNAVAQKQLGRLWH	acetylation	[1]
270	DQYIEQFKDTLSTSV	acetylation	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. 

Sequence Annotation

 MOD_RES 350 350 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Aminotransferase; Complete proteome; Direct protein sequencing; Mitochondrion; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 514 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0047305; F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity; IEA:EC.
 GO:0008453; F:alanine-glyoxylate transaminase activity; IDA:BHF-UCL.
 GO:0016223; F:beta-alanine-pyruvate transaminase activity; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019265; P:glycine biosynthetic process, by transamination of glyoxylate; IDA:BHF-UCL.
 GO:0009436; P:glyoxylate catabolic process; IDA:BHF-UCL.
 GO:0019481; P:L-alanine catabolic process, by transamination; IDA:BHF-UCL.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:BHF-UCL.
 GO:0006206; P:pyrimidine nucleobase metabolic process; TAS:Reactome.
 GO:0046135; P:pyrimidine nucleoside catabolic process; TAS:Reactome. 

Interpro

 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00202; Aminotran_3 

SMART

  

PROSITE

 PS00600; AA_TRANSFER_CLASS_3 

PRINTS