UniProt Accession

 E9PC49_HUMAN; E9PC49 

Genbank Protein ID

 AL133551 

Genbank Nucleotide ID

  

Protein Name

 SirtT1 75 kDa fragment 

Protein Synonyms/Alias

  

Gene Name

 SIRT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	KDPRPFFKFAKEIYP	ubiquitination	[1]
19	RPFFKFAKEIYPGQF	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005720; C:nuclear heterochromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0001678; P:cellular glucose homeostasis; IEA:Compara.
 GO:0071479; P:cellular response to ionizing radiation; IEA:Compara.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0035356; P:cellular triglyceride homeostasis; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0000731; P:DNA synthesis involved in DNA repair; IEA:Compara.
 GO:0055089; P:fatty acid homeostasis; IEA:Compara.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0042326; P:negative regulation of phosphorylation; IEA:Compara.
 GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IEA:Compara.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0032007; P:negative regulation of TOR signaling cascade; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0001542; P:ovulation from ovarian follicle; IEA:Compara.
 GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IEA:Compara.
 GO:0016239; P:positive regulation of macroautophagy; IEA:Compara.
 GO:2000111; P:positive regulation of macrophage apoptotic process; IEA:Compara.
 GO:0031648; P:protein destabilization; IEA:Compara.
 GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Compara.
 GO:0070857; P:regulation of bile acid biosynthetic process; IEA:Compara.
 GO:0010906; P:regulation of glucose metabolic process; IEA:Compara.
 GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; IEA:Compara.
 GO:0034391; P:regulation of smooth muscle cell apoptotic process; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006642; P:triglyceride mobilization; IEA:Compara.
 GO:0050872; P:white fat cell differentiation; IEA:Compara. 

Interpro

 IPR003000; Sirtuin.
 IPR026590; Ssirtuin_cat_dom. 

Pfam

 PF02146; SIR2 

SMART

  

PROSITE

 PS50305; SIRTUIN 

PRINTS