CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036466
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytochrome b5 
Protein Synonyms/Alias
  
Gene Name
 Cyb5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
53TDARELSKTYIIGELacetylation[1, 2, 3]
53TDARELSKTYIIGELubiquitination[4]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 110 AA 
Protein Sequence
MLRSVLNKCY PLAGRVHNRH PGGEEVLREQ AGGDATENFE DVGHSTDARE LSKTYIIGEL 60
HPDDRSKIAK PSDTLITTVE SNSSWWTNWV IPAISALAVA LMYRLYMAED 110 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; TAS:MGI.
 GO:0006631; P:fatty acid metabolic process; IC:MGI. 
Interpro
 IPR001199; Cyt_B5-like_heme/steroid-bd. 
Pfam
 PF00173; Cyt-b5 
SMART
  
PROSITE
 PS50255; CYTOCHROME_B5_2 
PRINTS
 PR00363; CYTOCHROMEB5.