UniProt Accession

 H2B1A_MOUSE; P70696; Q5NCL9 

Genbank Protein ID

 X90778; AY158939; AL606464 

Genbank Nucleotide ID

 CAA62299.1; AAO06249.1; CAI35973.1 

Protein Name

 Histone H2B type 1-A 

Protein Synonyms/Alias

 Histone H2B, testis; Testis-specific histone H2B 

Gene Name

 Hist1h2ba 

Gene Synonyms/Alias

 Th2b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
110	LLPGELAKHAVSEGT	acetylation	[1]
122	EGTKAVTKYTSSK**	acetylation	[1]

Reference

 [1] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
 Tweedie-Cullen RY, Reck JM, Mansuy IM.
 J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylproline (By similarity).
 MOD_RES 7 7 N6-acetyllysine; alternate (By
 MOD_RES 7 7 N6-crotonyl-L-lysine; alternate.
 MOD_RES 13 13 N6-acetyllysine; alternate (By
 MOD_RES 13 13 N6-crotonyl-L-lysine; alternate.
 MOD_RES 14 14 N6-acetyllysine; alternate (By
 MOD_RES 14 14 N6-crotonyl-L-lysine; alternate.
 MOD_RES 17 17 N6-acetyllysine; alternate (By
 MOD_RES 17 17 N6-crotonyl-L-lysine; alternate.
 MOD_RES 18 18 N6-acetyllysine; alternate (By
 MOD_RES 18 18 N6-crotonyl-L-lysine; alternate.
 MOD_RES 22 22 N6-acetyllysine; alternate (By
 MOD_RES 22 22 N6-crotonyl-L-lysine; alternate.
 MOD_RES 25 25 N6-acetyllysine; alternate (By
 MOD_RES 25 25 N6-crotonyl-L-lysine; alternate.
 MOD_RES 36 36 N6-crotonyl-L-lysine; alternate.
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 44 44 Phosphotyrosine (By similarity).
 MOD_RES 48 48 N6-methyllysine (By similarity).
 MOD_RES 59 59 N6,N6-dimethyllysine (By similarity).
 MOD_RES 110 110 N6-methyllysine (By similarity).
 MOD_RES 114 114 Phosphoserine (By similarity).
 CROSSLNK 36 36 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 122 122 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0071229; P:cellular response to acid; IDA:MGI.
 GO:0006954; P:inflammatory response; IMP:MGI.
 GO:0071674; P:mononuclear cell migration; IMP:MGI.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0031639; P:plasminogen activation; IMP:MGI.
 GO:0051099; P:positive regulation of binding; IMP:MGI. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.