CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038207
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor corepressor 2 
Protein Synonyms/Alias
  
Gene Name
 Ncor2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
335KVREYYEKQFPEIRKacetylation[1]
387SEQENLEKQMRQLAVubiquitination[2]
1916AGHAFLTKPPAREPAacetylation[1, 3]
1975ASDLHREKTQSKPFSacetylation[4]
1979HREKTQSKPFSIQELacetylation[1, 3, 4, 5]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2468 AA 
Protein Sequence
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT SHLSPGSIIQ 60
PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 120
SPLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELAPSRLSKE ELIQNMDRVD 180
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 420
KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480
SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 540
LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600
ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 660
ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 720
QASGNEVPRV GECSGPAAVN NSSDTESVPS PRSEATKDTG PKPTGTEALP AATQPPVPPP 780
EEPAVAPAEP SPVPDASGPP SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA 840
EEIDVGKPEE PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA 900
AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP RASTSPQKPL 960
DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT QHLQPEGDVS QQSGGSPRGK 1020
SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT EPPRWSSGLP FPIPPREVIK TSPHAADPSA 1080
FSYTPPGHPL PLGLHDSARP VLPRPPISNP PPLISSAKHP GVLERQLGAI SQGMSVQLRV 1140
PHSEHAKAPM GPLTMGLPLA VDPKKLGTAL GSATSGSITK GLPSTRAADG PSYRGSITHG 1200
TPADVLYKGT ISRIVGEDSP SRLDRAREDT LPKGHVIYEG KKGHVLSYEG GMSVSQCSKE 1260
DGRSSSGPPH ETAAPKRTYD MMEGRVGRTV TSASIEGLMG RAIPEQHSPH LKEQHHIRGS 1320
ITQGIPRSYV EAQEDYLRRE AKLLKREGTP PPPPPPRDLT ETYKPRPLDP LGPLKLKPTH 1380
EGVVATVKEA GRSIHEIPRE ELRRTPELPL APRPLKEGSI TQGTPLKYDS GAPSTGTKKH 1440
DVRSIIGSPG RPFPALHPLD IMADARALER ACYEESLKSR SGTSSGAGGS ITRGAPVVVP 1500
ELGKPRQSPL TYEDHGAPFT SHLPRGSPVT TREPTPRLQE GSLLSSKASQ DRKLTSTPRE 1560
IAKSPHSTVP EHHPHPISPY EHLLRGVTGV DLYRGHIPLA FDPTSIPRGI PLEAAAAAYY 1620
LPRHLAPSPT YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA SAMAQRADML 1680
RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT PATAIDRLAY LPTAPPPFSS 1740
RHSSSPLSPG GPTHLAKPTA TSSSERERER ERERDKSILT STTTVEHAPI WRPGTEQSSG 1800
AGGSSRPASH THQHSPISPR TQDALQQRPS VLHNTSMKGV VTSVEPGTPT VLRSTSTSSP 1860
VRPAATFPPA THCPLGGTLE GVYPTLMEPV LLPKETSRVA RPERPRVDAG HAFLTKPPAR 1920
EPASSPSKSS EPRSLAPPSS SHTAIARTPA KNLAPHHASP DPPAPTSASD LHREKTQSKP 1980
FSIQELELRS LGYHSGAGYS PDGVEPISPV SSPSLTHDKG LSKPLEELEK SHLEGELRHK 2040
QPGPMKLSAE AAHLPHLRPL PESQPSSSPL LQTAPGIKGH QRVVTLAQHI SEVITQDYTR 2100
HHPQQLSGPL PAPLYSFPGA SCPVLDLRRP PSDLYLPPPD HGTPARGSPH SEGGKRSPEP 2160
SKTSVLGSSE DAIEPVSPPE GMTEPGHARS TAYPLLYRDG EQGEPRMGSK SPGNTSQPPA 2220
FFSKLTESNS AMVKSKKQEI NKKLNTHNRN EPEYNIGQPG TEIFNMPAIT GAGLMTCRSQ 2280
AVQEHASTNM GLEAIIRKAL MGKYDQWEEP PPLGANAFNP LNASASLPAA AMPITTADGR 2340
SDHALTSPGG GGKAKVSGRP SSRKAKSPAP GLASGDRPPS VSSVHSEGDC NRRTPLTNRV 2400
WEDRPSSAGS TPFPYNPLIM RLQAGVMASP PPPGLAAGSG PLAGPHHAWD EEPKPLLCSQ 2460
YETLSDSE 2468 
Gene Ontology
 GO:0000785; C:chromatin; IEA:Compara.
 GO:0000118; C:histone deacetylase complex; IDA:MGI.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0001012; F:RNA polymerase II regulatory region DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IMP:MGI.
 GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
 GO:0060206; P:estrous cycle phase; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara.
 GO:0021537; P:telencephalon development; IMP:MGI.
 GO:0050872; P:white fat cell differentiation; IMP:MGI. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS