UniProt Accession

 GPT_HUMAN; Q9H3H5; O15216; Q86WV9; Q9BWE6 

Genbank Protein ID

 Z82022; AF070443; AF069061; BT006802; BC000325; BC047771 

Genbank Nucleotide ID

 CAB04787.1; AAG43168.1; AAG43168.1; AAP35448.1; AAH00325.1; AAH47771.1 

Protein Name

 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 

Protein Synonyms/Alias

 GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase 

Gene Name

 DPAGT1 

Gene Synonyms/Alias

 DPAGT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	LCGQDLNKTSRQQIP	ubiquitination	[1, 2, 3]
313	RLNIKTGKLEMSYSK	ubiquitination	[1]
320	KLEMSYSKFKTKSLS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides. 

Sequence Annotation

 MOTIF 67 79 Dolichol recognition.
 MOTIF 222 234 Dolichol recognition.
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Congenital disorder of glycosylation; Congenital myasthenic syndrome; Disease mutation; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 408 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IEA:InterPro.
 GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
 GO:0003975; F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; IDA:UniProtKB.
 GO:0019408; P:dolichol biosynthetic process; IDA:UniProtKB.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0051259; P:protein oligomerization; ISS:UniProtKB.
 GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:Compara. 

Interpro

 IPR000715; Glycosyl_transferase_4. 

Pfam

 PF00953; Glycos_transf_4 

SMART

  

PROSITE

  

PRINTS