CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029156
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal transducing adapter molecule 1 
Protein Synonyms/Alias
  
Gene Name
 STAM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22SLISAMIKNLKEQGVubiquitination[1, 2, 3, 4]
25SAMIKNLKEQGVTFPubiquitination[4, 5]
43SQAAEQAKASPALVAubiquitination[1, 2, 3, 4, 5, 6]
51ASPALVAKDPGTVANubiquitination[2, 3, 4, 6]
59DPGTVANKKEEEDLAacetylation[6]
59DPGTVANKKEEEDLAubiquitination[2, 3, 4, 5, 6]
60PGTVANKKEEEDLAKubiquitination[2, 3, 4]
74KAIELSLKEQRQQSTubiquitination[1, 2, 3, 4, 5, 6]
165TAEPEMIKTEKKTVQubiquitination[2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 173 AA 
Protein Sequence
MVEWTDEFKN DPQLSLISAM IKNLKEQGVT FPAIGSQAAE QAKASPALVA KDPGTVANKK 60
EEEDLAKAIE LSLKEQRQQS TTLSTLYPST SSLLTNHQHE GRKVRAIYDF EAAEDNELTF 120
KAGEIITVLD DSDPNWWKGE THQGIGLFPS NFVTADLTAE PEMIKTEKKT VQF 173 
Gene Ontology
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR000108; p67phox.
 IPR001452; SH3_domain.
 IPR003903; Ubiquitin-int_motif.
 IPR002014; VHS. 
Pfam
 PF00018; SH3_1
 PF02809; UIM 
SMART
 SM00326; SH3
 SM00726; UIM 
PROSITE
 PS50002; SH3
 PS50330; UIM
 PS50179; VHS 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.