UniProt Accession

 IPA3_YEAST; P01094; D6VZZ6 

Genbank Protein ID

 X60050; Z49808; AY558120; BK006946 

Genbank Nucleotide ID

 CAA42650.1; CAA89907.1; AAS56446.1; DAA10070.1 

Protein Name

 Protease A inhibitor 3 

Protein Synonyms/Alias

 Proteinase inhibitor I(A)3; Proteinase yscA-inhibitor; Saccharopepsin inhibitor 

Gene Name

 PAI3 

Gene Synonyms/Alias

 YMR174C; YM8010.04C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
59	NYQEQYNKLKGAGHK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity. 

Sequence Annotation

 REGION 1 32 Inhibitory domain.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Aspartic protease inhibitor; Complete proteome; Direct protein sequencing; Protease inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 68 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:SGD.
 GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0004866; F:endopeptidase inhibitor activity; IDA:SGD.
 GO:0007039; P:vacuolar protein catabolic process; IMP:SGD. 

Interpro

 IPR023223; DNA_polIII_IA3_alpha-helix.
 IPR019507; Prtase_A_inh_IA3.
 IPR008956; Prtase_A_inh_IA3_dom. 

Pfam

 PF10466; Inhibitor_I34 

SMART

  

PROSITE

  

PRINTS