UniProt Accession

 CASP7_MOUSE; P97864; O08669 

Genbank Protein ID

 U67321; D86353; Y13088; BC005428 

Genbank Nucleotide ID

 AAC53068.1; BAA19730.1; CAA73530.1; AAH05428.1 

Protein Name

 Caspase-7 

Protein Synonyms/Alias

 CASP-7; Apoptotic protease Mch-3; Cysteine protease LICE2; Caspase-7 subunit p20; Caspase-7 subunit p11 

Gene Name

 Casp7 

Gene Synonyms/Alias

 Lice2; Mch3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	INNKNFDKATGMDVR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity). 

Sequence Annotation

 ACT_SITE 144 144 By similarity.
 ACT_SITE 186 186 By similarity.
 MOD_RES 16 16 Phosphoserine.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Protease; Reference proteome; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004190; F:aspartic-type endopeptidase activity; IDA:MGI.
 GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0006917; P:induction of apoptosis; IGI:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IDA:MGI.
 GO:0016485; P:protein processing; IDA:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0001836; P:release of cytochrome c from mitochondria; IGI:MGI.
 GO:0009411; P:response to UV; IGI:MGI. 

Interpro

 IPR015471; Casp7.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20.
 IPR016129; Pept_C14_ICE_p20_AS.
 IPR002138; Pept_C14_p10.
 IPR002398; Pept_C14_p45.
 IPR015917; Pept_C14_p45_core. 

Pfam

 PF00656; Peptidase_C14 

SMART

 SM00115; CASc 

PROSITE

 PS01122; CASPASE_CYS
 PS01121; CASPASE_HIS
 PS50207; CASPASE_P10
 PS50208; CASPASE_P20 

PRINTS

 PR00376; IL1BCENZYME.