CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 
Protein Synonyms/Alias
 GMP-PDE alpha 
Gene Name
 Pde6a 
Gene Synonyms/Alias
 Mpa; Pdea 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
467CDNEEIQKILKTREVacetylation[1, 2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 This protein participates in processes of transmission and amplification of the visual signal. 
Sequence Annotation
 DOMAIN 73 222 GAF 1.
 DOMAIN 254 431 GAF 2.
 ACT_SITE 559 559 Proton donor (By similarity).
 METAL 563 563 Divalent metal cation 1 (By similarity).
 METAL 599 599 Divalent metal cation 1 (By similarity).
 METAL 600 600 Divalent metal cation 1 (By similarity).
 METAL 600 600 Divalent metal cation 2 (By similarity).
 METAL 720 720 Divalent metal cation 1 (By similarity).
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 856 856 Cysteine methyl ester (By similarity).
 LIPID 856 856 S-farnesyl cysteine (By similarity).  
Keyword
 Acetylation; Cell membrane; cGMP; Complete proteome; Hydrolase; Lipoprotein; Membrane; Metal-binding; Methylation; Prenylation; Reference proteome; Repeat; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MGEVTAEEVE KFLDSNIGFA KQYYNFHYRG KVISDLLGAK EAAVDFSNYH DVNSVEESEI 60
IFDLLRDVQE NLQAEKCTFN VMKKLCFLLR ADRMSLFMYR TRNGIAELAT RLFNVHKDAV 120
LEDCLVMPDS EIVFPLDMGV VGHVAHSKKI ANVPNTEEDE HFCDFVDNLT EYQTKNILAS 180
PIMNGKDVVA IIMAVNKIDE PHFTKRDEEI LLKYLNFVNL IMKVFHLSYL HNCETRRGQI 240
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEAP 300
AYSGPRTPDG REINFYKVID YILHGKEDIK VIPNPPADHW ALVSGLPTYV AQNGLICNIM 360
NAPAEDFFEF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDDMDETLM 420
ESLTQFLGWS VLNPDTYESM NKLENRKDIF QDIVKYHVKC DNEEIQKILK TREVYGKEPW 480
ECEEEELAEI LQGELPDAES YEINKFHFSD LPLTELELVK CGIQMYYELR VVDKFHIPQE 540
ALVRFMYSLS KGYRRITYHN WRHGFNVGQT MFSLLVTGKL KRYFTDLEAL AMVTAAFCHD 600
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 660
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YESTQEWTQY MMLEQTRKEI VMAMMMTACD 720
LSAITKPWEV QSKVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 780
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYEAKM KALEEEKQKQ QAAKQAASGN 840
QPGGNPLQGA PASKSCCIQ 859 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.