UniProt Accession

 GLRX1_MOUSE; Q9QUH0 

Genbank Protein ID

 AB013137; AF109314; AF276917; BC012642 

Genbank Nucleotide ID

 BAA86926.1; AAF04780.1; AAF86464.1; AAH12642.1 

Protein Name

 Glutaredoxin-1 

Protein Synonyms/Alias

 Thioltransferase-1; TTase-1 

Gene Name

 Glrx 

Gene Synonyms/Alias

 Glrx1; Grx; Grx1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	AQEFVNCKIQSGKVV	acetylation	[1]
9	AQEFVNCKIQSGKVV	succinylation	[1]
14	NCKIQSGKVVVFIKP	acetylation	[2]
20	GKVVVFIKPTCPYCR	acetylation	[2, 3]
28	PTCPYCRKTQEILSQ	acetylation	[2]
28	PTCPYCRKTQEILSQ	ubiquitination	[4]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. 

Sequence Annotation

 DOMAIN 3 106 Glutaredoxin.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 23 26 Redox-active.
 DISULFID 79 83 By similarity.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Disulfide bond; Electron transport; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 107 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0019153; F:protein-disulfide reductase (glutathione) activity; TAS:MGI.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR011767; GLR_AS.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR014025; Glutaredoxin_subgr.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2 

PRINTS

 PR00160; GLUTAREDOXIN.