CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001630
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 11 
Protein Synonyms/Alias
  
Gene Name
 ZBTB11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30PGTEGNVKRKIRKAAubiquitination[1, 2]
110RGILKQVKDYIKQCSubiquitination[2]
114KQVKDYIKQCSKCQEubiquitination[2]
186ELVFVDTKGVVKRSSubiquitination[2]
202KHCQAVLKQLNEQRLubiquitination[2]
246FRDLFIEKGAVSSHEubiquitination[2]
314VHKLMEEKQLTVYKKubiquitination[2]
321KQLTVYKKGEVQTVAubiquitination[2, 3]
792MNKHLGVKPFQCQFCubiquitination[2]
834CGKEFYEKALFRRHVubiquitination[2]
944HRDYVPCKIMLEKDTubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 214 282 BTB.
 ZN_FING 569 591 C2H2-type 1.
 ZN_FING 597 619 C2H2-type 2.
 ZN_FING 651 673 C2H2-type 3.
 ZN_FING 679 701 C2H2-type 4.
 ZN_FING 707 729 C2H2-type 5.
 ZN_FING 735 757 C2H2-type 6.
 ZN_FING 766 788 C2H2-type 7.
 ZN_FING 794 816 C2H2-type 8.
 ZN_FING 822 846 C2H2-type 9.
 ZN_FING 858 880 C2H2-type 10.
 ZN_FING 886 908 C2H2-type 11.
 ZN_FING 914 937 C2H2-type 12.
 MOD_RES 1050 1050 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1053 AA 
Protein Sequence
MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRQRHRKTFA 60
ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY WWRGILKQVK DYIKQCSKCQ 120
EKLDRSRPIS DVSEMLEELG LDLESGEESN ESEDDLSNFT SSPTTASKPA KKKPVSKHEL 180
VFVDTKGVVK RSSPKHCQAV LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR 240
DLFIEKGAVS SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV 300
LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT TTSLPTELGD 360
CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG CIADSHPEME SVDLITKNNQ 420
TELETSNNRE NNTVSNIHPK LSKENVISSS PEDSGMGNDI SAEDICAEDI PKHRQKVDQP 480
LKDQENLVAS TAKTDFGPDD DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ 540
QVAQKLVQRG KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP 600
LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE FICSICGRTL 660
PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL HQSQKQFQCE LCVKSFVTKR 720
SLQEHMSIHT GESKYLCSVC GKSFHRGSGL SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD 780
LRQHMNKHLG VKPFQCQFCD KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH 840
VKKATHGKKG RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS 900
LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD TLQFHNQGTQ 960
VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA ATEEYPSVST LSDQSIMQVV 1020
NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS GGE 1053 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB
 PF00096; zf-C2H2 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS