| Tag | Content |
|---|
| CPLM ID | CPLM-020273 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Replication initiator 1 |
Protein Synonyms/Alias | 60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; ATT-binding protein; DHFR oribeta-binding protein RIP60; Zinc finger protein 464 |
Gene Name | REPIN1 |
Gene Synonyms/Alias | RIP60; ZNF464 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 33 | ESPQTLGKESRGLRQ | acetylation | [1] | | 276 | CGKRFTNKPYLTSHR | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending. |
Sequence Annotation | ZN_FING 57 79 C2H2-type 1; atypical.
ZN_FING 85 107 C2H2-type 2.
ZN_FING 116 138 C2H2-type 3.
ZN_FING 145 168 C2H2-type 4.
ZN_FING 177 199 C2H2-type 5.
ZN_FING 236 258 C2H2-type 6.
ZN_FING 264 286 C2H2-type 7.
ZN_FING 292 314 C2H2-type 8.
ZN_FING 375 397 C2H2-type 9.
ZN_FING 403 425 C2H2-type 10.
ZN_FING 431 453 C2H2-type 11.
ZN_FING 459 481 C2H2-type 12.
ZN_FING 487 509 C2H2-type 13.
ZN_FING 515 537 C2H2-type 14.
ZN_FING 543 565 C2H2-type 15.
MOD_RES 27 27 Phosphoserine.
MOD_RES 33 33 N6-acetyllysine.
MOD_RES 276 276 N6-acetyllysine. |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; DNA replication; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 567 AA |
Protein Sequence | MLERRCRGPL AMGLAQPRLL SGPSQESPQT LGKESRGLRQ QGTSVAQSGA QAPGRAHRCA 60
HCRRHFPGWV ALWLHTRRCQ ARLPLPCPEC GRRFRHAPFL ALHRQVHAAA TPDLGFACHL 120
CGQSFRGWVA LVLHLRAHSA AKRPIACPKC ERRFWRRKQL RAHLRRCHPP APEARPFICG 180
NCGRSFAQWD QLVAHKRVHV AEALEEAAAK ALGPRPRGRP AVTAPRPGGD AVDRPFQCAC 240
CGKRFRHKPN LIAHRRVHTG ERPHQCPECG KRFTNKPYLT SHRRIHTGEK PYPCKECGRR 300
FRHKPNLLSH SKIHKRSEGS AQAAPGPGSP QLPAGPQESA AEPTPAVPLK PAQEPPPGAP 360
PEHPQDPIEA PPSLYSCDDC GRSFRLERFL RAHQRQHTGE RPFTCAECGK NFGKKTHLVA 420
HSRVHSGERP FACEECGRRF SQGSHLAAHR RDHAPDRPFV CPDCGKAFRH KPYLAAHRRI 480
HTGEKPYVCP DCGKAFSQKS NLVSHRRIHT GERPYACPDC DRSFSQKSNL ITHRKSHIRD 540
GAFCCAICGQ TFDDEERLLA HQKKHDV 567 |
Gene Ontology | GO:0005664; C:nuclear origin of replication recognition complex; TAS:ProtInc. GO:0003677; F:DNA binding; TAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006260; P:DNA replication; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |