| Tag | Content |
|---|
| CPLM ID | CPLM-001759 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glutathione reductase, mitochondrial |
Protein Synonyms/Alias | GR; GRase |
Gene Name | GSR |
Gene Synonyms/Alias | GLUR; GRD1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 303 | TKDLSLNKLGIQTDD | ubiquitination | [1] | | 398 | KYGIENVKTYSTSFT | ubiquitination | [1] | | 458 | AVKMGATKADFDNTV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Maintains high levels of reduced glutathione in the cytosol. |
Sequence Annotation | NP_BIND 94 102 FAD.
ACT_SITE 511 511 Proton acceptor.
DISULFID 102 107 Redox-active.
DISULFID 134 134 Interchain. |
Keyword | 3D-structure; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Redox-active center; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 522 AA |
Protein Sequence | MACRQEPQPQ GPPPAAGAVA SYDYLVIGGG SGGLASARRA AELGARAAVV ESHKLGGTCV 60
NVGCVPKKVM WNTAVHSEFM HDHADYGFPS CEGKFNWRVI KEKRDAYVSR LNAIYQNNLT 120
KSHIEIIRGH AAFTSDPKPT IEVSGKKYTA PHILIATGGM PSTPHESQIP GASLGITSDG 180
FFQLEELPGR SVIVGAGYIA VEMAGILSAL GSKTSLMIRH DKVLRSFDSM ISTNCTEELE 240
NAGVEVLKFS QVKEVKKTLS GLEVSMVTAV PGRLPVMTMI PDVDCLLWAI GRVPNTKDLS 300
LNKLGIQTDD KGHIIVDEFQ NTNVKGIYAV GDVCGKALLT PVAIAAGRKL AHRLFEYKED 360
SKLDYNNIPT VVFSHPPIGT VGLTEDEAIH KYGIENVKTY STSFTPMYHA VTKRKTKCVM 420
KMVCANKEEK VVGIHMQGLG CDEMLQGFAV AVKMGATKAD FDNTVAIHPT SSEELVTLR 479 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0009055; F:electron carrier activity; TAS:UniProtKB. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0004362; F:glutathione-disulfide reductase activity; TAS:Reactome. GO:0050661; F:NADP binding; IEA:InterPro. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0006749; P:glutathione metabolic process; IEA:InterPro. GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |