CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014869
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aminoacylase-1A 
Protein Synonyms/Alias
 ACY-1A; ACY IA; N-acyl-L-amino-acid amidohydrolase 
Gene Name
 Acy1a 
Gene Synonyms/Alias
 Acy1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
4****MTTKGPESEHPacetylation[1]
153DEEVGGHKGMELFVKacetylation[1]
160KGMELFVKRPEFQALacetylation[1]
218IEDTAAEKLHKVVNSacetylation[1]
221TAAEKLHKVVNSILAacetylation[1]
232SILAFREKERQRLQAacetylation[1]
244LQANPHLKEGAVTSVacetylation[1]
284VAPDVDMKAFEKQLQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) (By similarity). 
Sequence Annotation
 ACT_SITE 82 82 By similarity.
 ACT_SITE 147 147 Proton acceptor (By similarity).
 METAL 80 80 Zinc 1 (By similarity).
 METAL 113 113 Zinc 1 (By similarity).
 METAL 113 113 Zinc 2 (By similarity).
 METAL 148 148 Zinc 2 (By similarity).
 METAL 175 175 Zinc 1 (By similarity).
 METAL 373 373 Zinc 2 (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MTTKGPESEH PSVTLFRQYL RICTVQPNPD YGSAVTFLEE RARQLGLSCQ KIEVAPGYVI 60
TVLTWPGTNP LLHSILLNSH TDVVPVFKEH WHHDPFEAFK DSEGYIYARG AQDMKSVSIQ 120
YLEAVRRLKS EGHRFPRTIH MTFVPDEEVG GHKGMELFVK RPEFQALRAG FALDEGLANP 180
TDAFTVFYSE RSPWWIRVTS TGKPGHASRF IEDTAAEKLH KVVNSILAFR EKERQRLQAN 240
PHLKEGAVTS VNLTKLEGGV AYNVVPATMS ACFDFRVAPD VDMKAFEKQL QSWCQEAGEG 300
VTFEFAQKFT EPRMTPTDDT DPWWAAFSGA CKEMNLTLEP EIFPAATDSR YIRAVGIPAL 360
GFSPMNRTPV LLHDHNERLH EAVFLRGVDI YTRLVAALAS VPALPGES 408 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004046; F:aminoacylase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
 GO:0030163; P:protein catabolic process; TAS:RGD.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR001261; ArgE/DapE_CS.
 IPR010159; N-acyl_aa_amidohydrolase.
 IPR002933; Peptidase_M20.
 IPR011650; Peptidase_M20_dimer. 
Pfam
 PF07687; M20_dimer
 PF01546; Peptidase_M20 
SMART
  
PROSITE
 PS00758; ARGE_DAPE_CPG2_1
 PS00759; ARGE_DAPE_CPG2_2 
PRINTS