UniProt Accession

 CAPZB_BOVIN; P79136; Q3T012 

Genbank Protein ID

 Z85980; Y10372; BC102613 

Genbank Nucleotide ID

 CAB06626.1; CAA71401.1; AAI02614.1 

Protein Name

 F-actin-capping protein subunit beta 

Protein Synonyms/Alias

 CapZ beta 

Gene Name

 CAPZB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
281	SVQTFADKSKQEALK	ubiquitination	[1]
283	QTFADKSKQEALKND	ubiquitination	[1]
288	KSKQEALKNDLVEAL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The isoform beta-3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. May play a role in the regulation of cell morphology and cytoskeletal organization. 

Sequence Annotation

 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 264 264 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin capping; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.