UniProt Accession

 G3V5Z3_HUMAN; G3V5Z3 

Genbank Protein ID

 AL133153 

Genbank Nucleotide ID

  

Protein Name

 Uncharacterized protein 

Protein Synonyms/Alias

  

Gene Name

 SMEK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
553	KRKIIGLKDEFYNRY	ubiquitination	[1]
563	FYNRYIMKSFLFEPV	ubiquitination	[1]
572	FLFEPVVKAFLNNGS	ubiquitination	[1]
642	RERQDNPKLDSMRSI	acetylation	[2, 3, 4]
642	RERQDNPKLDSMRSI	methylation	[5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 706 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030289; C:protein phosphatase 4 complex; IEA:Compara.
 GO:0045722; P:positive regulation of gluconeogenesis; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:Compara. 

Interpro

 IPR016024; ARM-type_fold.
 IPR006887; DUF625.
 IPR011993; PH_like_dom. 

Pfam

 PF04802; SMK-1 

SMART

  

PROSITE

  

PRINTS