CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingomyelin phosphodiesterase 4 
Protein Synonyms/Alias
 Neutral sphingomyelinase 3; nSMase-3; nSMase3; Neutral sphingomyelinase III 
Gene Name
 Smpd4 
Gene Synonyms/Alias
 Kiaa1418 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
413PWRYAPEKQAQGSDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (By similarity). 
Sequence Annotation
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 665 665 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 823 AA 
Protein Sequence
MAFPHLQQPS FLLASLKADS INKPFAQRCQ DLVKVIEDFP AKELHAVFPW LVESIFGSLD 60
GVLVGWNLRC LQGRVNPVEY STAMEFLDPS GPMMKLVYKL QAEDYNFDFP VSCLPGPVKA 120
SIQENVLPDS PLYHNKVQFP PTGGLGLNLA LNPFEYYMFY FALSLISQKP MSMTLHVRTS 180
DCAYFTLVDR YLSWFLPTEG SVPPPLCSSP GGSSPSPAPR TPAMPFASYG LHTSLLKRHI 240
SHQTSVNADP ASHEIWRSET LLQVFVEMWL HHYSLEMYQK MQSPHAKLEV LHYRLTVSSA 300
LHSPAQPSLQ ALHAYQESFT PTEEHVLVVR LLLKHLHAFA NSLKPDQASP SAHSHATSPL 360
EEFKRAAVPR FVQQKLYVFL QHCFGHWPLD ATFRAVLEMW LSYLQPWRYA PEKQAQGSDP 420
QPRCVSEKWA PFIQENLLMY TKLFVSFLNR ALRTDLVSPK NALMVFRVAK VFAQPNLAEM 480
IQKGEQLFLE PELIIPHRQH RLFTVTTSFL SPWPPVVTDA SFKVKSHVYS LEGQDCKYTP 540
MFGPEIRTLV LRLAQLITQA KQTAKSISDQ YVESPTGRSF LSWLTFGLTD TNSCYPANDL 600
DEIGQDSIRK TDEYLEKALE YLRQIFRLSE AQLAQLTLAL GSARDENGKQ QLPDCIVGEE 660
GLILTPLGRY QIINGLRRFE IEYQGDLELQ PIRSYEITSL VRALFRLSSA INRRFAGQMA 720
ALCSRNDFLG SFCRYHLTEP ALSNRHLLSP VGRRQVTNPA RGPRLSLRFL GSYRTLLLLL 780
MAFFVASLFC IGPLSCSLLL VLGYVLYAIA MTLLTERGKL HQL 823 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; ISS:HGNC.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005802; C:trans-Golgi network; ISS:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
 GO:0050290; F:sphingomyelin phosphodiesterase D activity; ISS:HGNC.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0046513; P:ceramide biosynthetic process; IEA:Compara.
 GO:0046475; P:glycerophospholipid catabolic process; IEA:Compara.
 GO:0006685; P:sphingomyelin catabolic process; ISS:HGNC. 
Interpro
 IPR024129; Sphingomy_SMPD4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS