CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aquarius homolog (Mouse), isoform CRA_a 
Protein Synonyms/Alias
 Intron-binding protein aquarius 
Gene Name
 AQR 
Gene Synonyms/Alias
 hCG_38784 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MAAPAQPKKIVAPTVubiquitination[1]
9AAPAQPKKIVAPTVSubiquitination[1]
52VIEDIYEKEIVKSRFubiquitination[1]
188ARLELELKKTPKLRKubiquitination[1]
201RKFWNLIKKNDEKMDubiquitination[2, 3]
246SEPVTMDKVHYCERFubiquitination[1, 4]
493EDSVSRMKPWQSEYGubiquitination[1]
576PTKPYGTKFDRRRPFacetylation[5]
604IQGMLDDKGRVIEDGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 646 AA 
Protein Sequence
MAAPAQPKKI VAPTVSQINA EFVTQLACKY WAPHIKKKSP FDIKVIEDIY EKEIVKSRFA 60
IRKIMLLEFS QYLENYLWMN YSPEVSSKAY LMSICCMVNE KFRENVPAWE IFKKKPDHFP 120
FFFKHILKAA LAETDGEFSL HEQTVLLLFL DHCFNSLEVD LIRSQVQQLI SLPMWMGLQL 180
ARLELELKKT PKLRKFWNLI KKNDEKMDPE AREQAYQERR FLSQLIQKFI SVLKSVPLSE 240
PVTMDKVHYC ERFIELMIDL EALLPTRRWF NTILDDSHLL VHCYLSNLVR REEDGHLFSQ 300
LLDMLKFYTG FEINDQTGNA LTENEMTTIH YDRITSLQRA AFAHFPELYD FALSNVAEVD 360
TRESLVKFFG PLSSNTLHQV ASYLCLLPTL PKNEDTTFDK EFLLELLVSR HERRISQIQQ 420
LNQMPLYPTE KIIWDENIVP TEYYSGEGCL ALPKLNLQFL TLHDYLLRNF NLFRLESTYE 480
IRQDIEDSVS RMKPWQSEYG GVVFGGWARM AQPIVAFTVV EVAKPNIGEN WPTRVRADVT 540
INLNVRDHIK DEWEGLRKHD VCFLITVRPT KPYGTKFDRR RPFIEQVGLV YVRGCEIQGM 600
LDDKGRVIED GMVTYIFERD LNPDPILEEN QGHLECFWIQ TSINKI 646 
Gene Ontology
 GO:0005681; C:spliceosomal complex; IEA:InterPro.
 GO:0097157; F:pre-mRNA intronic binding; IEA:InterPro.
 GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. 
Interpro
 IPR024860; Aquarius. 
Pfam
  
SMART
  
PROSITE
  
PRINTS