UniProt Accession

 ISG20_MOUSE; Q9JL16; Q9CPZ5 

Genbank Protein ID

 AF217484; AK008139; AK008171; AK008353; BC022751 

Genbank Nucleotide ID

 AAF59917.1; BAB25487.1; BAB25509.1; BAB25623.1; AAH22751.1 

Protein Name

 Interferon-stimulated gene 20 kDa protein 

Protein Synonyms/Alias

 Promyelocytic leukemia nuclear body-associated protein ISG20; Protein DnaQL 

Gene Name

 Isg20 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
82	LEILQLLKGKLVVGH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. May be involved in the antiviral function of IFN against RNA viruses (By similarity). 

Sequence Annotation

 METAL 11 11 Manganese 1 (By similarity).
 METAL 13 13 Manganese 1 (By similarity).
 METAL 90 90 Manganese 2 (By similarity).
 METAL 93 93 Manganese 2 (By similarity).  

Keyword

 Alternative splicing; Antiviral defense; Complete proteome; Exonuclease; Hydrolase; Immunity; Innate immunity; Manganese; Metal-binding; Nuclease; Nucleus; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0016605; C:PML body; IEA:Compara.
 GO:0000175; F:3'-5'-exoribonuclease activity; IEA:Compara.
 GO:0008859; F:exoribonuclease II activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; IEA:Compara.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0000738; P:DNA catabolic process, exonucleolytic; IEA:Compara.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0006401; P:RNA catabolic process; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF00929; RNase_T 

SMART

 SM00479; EXOIII 

PROSITE

  

PRINTS