CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009999
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Major cardiolipin synthase ClsA 
Protein Synonyms/Alias
 CL synthase 2 
Gene Name
 clsA 
Gene Synonyms/Alias
 ywnE; BSU36590 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
142LSDISKAKDHIHLQYacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. 
Sequence Annotation
 DOMAIN 217 244 PLD phosphodiesterase 1.
 DOMAIN 395 422 PLD phosphodiesterase 2.
 ACT_SITE 222 222 Potential.
 ACT_SITE 224 224 Potential.
 ACT_SITE 229 229 Potential.
 ACT_SITE 400 400 Potential.
 ACT_SITE 402 402 Potential.
 ACT_SITE 407 407 Potential.  
Keyword
 Cell membrane; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MSISSILLSL FFILNILLAI IVIFKERRDA SASWAWLLVL FFIPVLGFIL YLLFGHNLRR 60
KHLFQWEDRK KIGIERLLKH QLEDLETKQF QFNNRATFDN KDLIYMLIMN NHAVFTEDNS 120
VDVITDGRDK FQRLLSDISK AKDHIHLQYY IYKGDELGKK LRDALIQKAK EGVQVRVLYD 180
ELGSRTLRKK FFKELREAGG HVEVFFPSKL RPINLRLNYR NHRKLVIIDG MTGYVGGFNV 240
GDEYLGLNPK FGYWRDTHIR LQGTAVHAIQ TRFILDWNQA SHHHTLTYIP NHFPDYGPKG 300
NVGMQIVTSG PDSEWEQIKN GYIKMISNAK RSILIQTPYF IPDASLLDAL RIACLSGIDV 360
NIMIPNKPDH AFVYWATLSY IGDLLKAGAT VYIYDNGFIH AKTIVVDDEI ASVGTANIDV 420
RSFRLNFEVN AFIYDITIAK KLVSTFKEDL LVSRKFTYEE YLQRPLWIRI KESVSRLLSP 480
IL 482 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008808; F:cardiolipin synthase activity; IMP:UniProtKB.
 GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
 GO:0043934; P:sporulation; IMP:UniProtKB. 
Interpro
 IPR022924; Cardiolipin_synthase.
 IPR027379; CLS_N.
 IPR025202; PLD-like_dom.
 IPR001736; PLipase_D/transphosphatidylase.
 IPR015679; PLipase_D_fam. 
Pfam
 PF13091; PLDc_2
 PF13396; PLDc_N 
SMART
 SM00155; PLDc 
PROSITE
 PS50035; PLD 
PRINTS