UniProt Accession

 ROA1_MOUSE; P49312; P97312; Q3V269 

Genbank Protein ID

 M99167; D86729; D86728; AK007802; AK088308; AK131999; AK135391; AK161730; AK166901; AK167161; AK167810; AK167913; AK168420; AK168531; BC080675; BC083136 

Genbank Nucleotide ID

 AAA37633.1; BAA13162.1; BAA13161.1; BAB25267.1; BAC40273.1; BAE20929.1; BAE22518.1; BAE36552.1; BAE39104.1; BAE39302.1; BAE39837.1; BAE39920.1; BAE40333.1; BAE40409.1; AAH80675.1; AAH83136.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A1 

Protein Synonyms/Alias

 hnRNP A1; HDP-1; Helix-destabilizing protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed; hnRNP core protein A1 

Gene Name

 Hnrnpa1 

Gene Synonyms/Alias

 Fli-2; Hnrpa1; Tis 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
298	GGGQYFAKPRNQGGY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. 

Sequence Annotation

 DOMAIN 14 97 RRM 1.
 DOMAIN 105 184 RRM 2.
 REGION 4 94 Globular A domain.
 REGION 95 185 Globular B domain.
 REGION 218 240 RNA-binding RGG-box.
 REGION 268 305 Nuclear targeting sequence (By
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 6 6 Phosphoserine.
 MOD_RES 192 192 Phosphoserine; by MKNK2 (By similarity).
 MOD_RES 194 194 Asymmetric dimethylarginine; alternate
 MOD_RES 194 194 Dimethylated arginine; alternate (By
 MOD_RES 194 194 Omega-N-methylated arginine; alternate
 MOD_RES 199 199 Phosphoserine (By similarity).
 MOD_RES 206 206 Dimethylated arginine; alternate (By
 MOD_RES 206 206 Omega-N-methylarginine; alternate (By
 MOD_RES 225 225 Dimethylated arginine; alternate (By
 MOD_RES 225 225 Omega-N-methylarginine; alternate (By
 MOD_RES 298 298 N6-acetyllysine (By similarity).
 MOD_RES 310 310 Phosphoserine; by MKNK2 (By similarity).
 MOD_RES 311 311 Phosphoserine; by MKNK2 (By similarity).
 MOD_RES 312 312 Phosphoserine; by MKNK2 (By similarity).
 MOD_RES 313 313 Phosphoserine.
 MOD_RES 316 316 Phosphoserine (By similarity).
 CROSSLNK 113 113 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Methylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:HGNC.
 GO:0005654; C:nucleoplasm; ISS:HGNC.
 GO:0005681; C:spliceosomal complex; ISS:HGNC.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003697; F:single-stranded DNA binding; ISS:HGNC.
 GO:0000380; P:alternative mRNA splicing, via spliceosome; IDA:MGI.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051168; P:nuclear export; ISS:HGNC.
 GO:0051170; P:nuclear import; ISS:HGNC. 

Interpro

 IPR021662; HnRNPA1.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF11627; HnRNPA1
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS