CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein M1 
Protein Synonyms/Alias
 Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cells 
Gene Name
 FOXM1 
Gene Synonyms/Alias
 FKHL16; HFH11; MPP2; WIN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
278PYFKHIAKPGWKNSImethylation[1]
282HIAKPGWKNSIRHNLmethylation[1]
443AGPGKEEKLLFGEGFubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. 
Sequence Annotation
 DNA_BIND 235 327 Fork-head.
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 376 376 Phosphoserine; by CHEK2.
 MOD_RES 611 611 Phosphothreonine; by CDK1.
 MOD_RES 620 620 Phosphothreonine.
 MOD_RES 627 627 Phosphothreonine.
 MOD_RES 662 662 Phosphothreonine (Probable).
 MOD_RES 693 693 Phosphoserine; by CDK1.
 MOD_RES 730 730 Phosphoserine; by PLK1.
 MOD_RES 739 739 Phosphoserine; by PLK1.  
Keyword
 3D-structure; Activator; Alternative splicing; Cell cycle; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 763 AA 
Protein Sequence
MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 60
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 120
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 180
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 240
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 300
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 360
LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 420
PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE 480
SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE 540
RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT 600
PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS 660
TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE 720
GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ 763 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0019904; F:protein domain specific binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0007049; P:cell cycle; TAS:UniProtKB.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IMP:UniProtKB.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0001889; P:liver development; IBA:RefGenome.
 GO:0090344; P:negative regulation of cell aging; IMP:UniProtKB.
 GO:0032873; P:negative regulation of stress-activated MAPK cascade; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
 GO:2000781; P:positive regulation of double-strand break repair; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0071156; P:regulation of cell cycle arrest; IMP:BHF-UCL.
 GO:0001558; P:regulation of cell growth; TAS:UniProtKB.
 GO:0042127; P:regulation of cell proliferation; NAS:UniProtKB.
 GO:0046578; P:regulation of Ras protein signal transduction; IMP:BHF-UCL.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0009888; P:tissue development; IBA:RefGenome.
 GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0001570; P:vasculogenesis; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.