CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028465
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Bptf 
Protein Synonyms/Alias
  
Gene Name
 Bptf 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1228KPPMGALKSSSESPGacetylation[1]
1228KPPMGALKSSSESPGsuccinylation[1]
1479CEDKLQGKVTEANGKacetylation[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3036 AA 
Protein Sequence
MRGRRGRPPK QPAAPAAERC APAPPPPPPP PPPPPPPPPP PPPASGPIGG LRSRHRGSSR 60
GRWAAAQAEV APKTRLSSPR GGGRRKQPPP PPPASGSSAS GPGRGGRGGG GGRTGGGGGH 120
LARTTPARRA VNKVVYDDHE SDDDDEEEDM VSEEDEEEEE DGDAEETQDS EDEEEDDMEE 180
DDDDSDYPEE MEDDDDDASY CTESSFRSHS TYSSTPGRRK PRVHRPRSPI LEEKDIPPLE 240
FPKSSEDLMV PNEHIMNVIA IYEVVRNFGN VLRLSPFCFE DFCAALVSQE QCTLMAEMHV 300
ALLKAVLREE DTSNTTFGPA DLKDSVNSTL YFIDGMTWPE VLRVYCESDK EYHHVLPYQE 360
AEDYPYGPVE NKIKVLQFLV DQFLTTNIAR EELMSEGVIQ YDDHCRVCHK LGDLLCCETC 420
SAVYHLECVK PPLEEVPEDE WQCEVCVAHK VPGVTDCVAE VQKNKPYVRH EPIGYDRSRR 480
KYWFLNRRLI IEEDTDNENE KKVWYYSTKV QLAELIDCLD KGYWEAELCR VLEDIREEMQ 540
QHMDVTEDLT NKARGSNKSF LAAANEEILD SLRIKRGEDI DCDQSPEDPE KDKHEGENNS 600
SKDAEKSREE AEDPSADKDA DSKGLEEEPG HGKPEEPTEV GDKGNSVPAN LGDNTTNASP 660
EETSPCDGRS PEGCLSETHD SSSMAEKKVA SELPPDVPED SNRTCDSSNT SATTASSQPN 720
LETCSSSELT SSQSDSAKAA DDPEIGERDS HTPVSVHEEI GDFRLEKSNG EVSESPGAGK 780
GTSGSTRIIT RLRNPESKLS QLKSQQVAAA AHEANKLFKE GKEVLVVNSQ GEVSRLSTKK 840
EVVMKGNINN YFKLGQEGKY RVYHNQYSTN SFALNKHQHR EDHDKRRHLA HKFCLTPAGE 900
FKWNGSVHGS KVLTISTLRL TITQLESNIP SSFLHPNWAS HRANWIKAVQ MCSKPREFAL 960
ALAILECAVK PVVMLPIWRE SLGHTRLHRM TSIEREEKEK VKKKEKKQEE EETMQQATWV 1020
KYTFPVKHQV TGYGGWSWIS KTHVYRFLPK LPGNTNVNYR KPLDGAKNNT DENKDESEKR 1080
KSPRSPKKMK TECDSEQGET RDADATAGAA AGAMELSKEP EKKDQDVKEL LDSDNDKSFK 1140
EEPMEIDDTI KTESHVSSLE STEVDVVNVS EGFHLRTSYK KKTKSSKLDG LLERRIRQFT 1200
LEEKQRLEKL KLESGVKGAG KPPMGALKSS SESPGSTKAS EGHQGDSLRQ EQSPSSSQAS 1260
TVDLGLGGSQ SDPLVLGISP PSLSTHKPDP KDQVLDDVSI QSPGPNCQRQ NSVESDLDAR 1320
ISEPAGKGLE LSQTKTEVTD SSSDDSKPTS ADDVGILICK SRKLHSQDDS STVVSSSKST 1380
LPASVPKSPR DRDARAFSKA VDFDGRLGGD SEYSSTLENS SDNMCIRDSA EEDMVVQNSS 1440
EATSKRFIAP EQGGESVEST KCQVVSKSTE NCEDKLQGKV TEANGKKLGQ HPPKPEERAV 1500
NRCTDQVSLR HSVDRKNSEP RESEKKGQKA NKFQINGKDS KAKGYLKGPG TKDGSDGKVV 1560
SSAVEPKVNN INKVIPGNTK SLAGKESAAK PFINGDIIME ELSEQNTSET NSYSLSSSDA 1620
KGNHQDGLHT LPSTKESAST QVITPRAPCP DRNSLSQVED METESPEVKR VIPSPVRTGE 1680
GSNLSKGFMD DNGLPSSKDE NVNGESQRKT VITEVTTMTS TVATESKTVI KVAKGDKQTV 1740
VSSTENCARS TVTTTTTTVT KLSTPSPDTG VDTISVKEQS KTVVTTTVTD SLTTAGSTLV 1800
TSMTVSKEYS TRDRVKLMKF SRPKKTRSGT ALPSYRKFVT KSSKKSIFVL PNDDLKKLAR 1860
KGGIREVPYF NYNAKPALDI WPYPSPRPTF GITWRYRLQT VKSLAGVSLM LRLLWASLRW 1920
DDMAAKAPPG GGSTRTETSE TEITTTEIIK RRDVGPYGIR SEYCIRKIIC PIGVPEAPKE 1980
TPTPQRKGLR SSALRPKRPE TPKQTGPVII ESWVAEEELE LWEIRAFAER VEKEKAQAAE 2040
QQTKKRLEQQ KPAVIAASTT SPANNTSSTV SPAQKVMVAP LSGSVTPGTK MVLATKVGSP 2100
ATVTFQQNKN FHQTFATWVK QGQSNSGMVQ VQQKVLGIIP STTGPSQQTF TSFQPRTATV 2160
TIRPNTSASA GTTTTSQVIT GPQIRPGMTV IRTPLQQPAL GKAIIRTPVV VQPGTPQQVV 2220
TQIIRGQPVS TAISAPSTAS SAPVQKGLTP GAAAGPLQPS APHSPRPQQG QVKLTMAQLT 2280
QLTQGHGGNQ GLTVVIQGQG QTTGQLQLIP QGMTVLPGPG QQLMQAAMPN GTVQRFLFTP 2340
LSTSATAASS SSNSSSTTTN ATAAGSGEQK QSKILPQTQV QPATTLAPTQ SSSVSPAEAQ 2400
PQPAQPAAQP QPQPQPPAQP EVQTQPAVSS HVPSETQPSQ AQTSKPLVAT QCQPQSSVQG 2460
QSPVRVQSPP LTRIRPSTPS QVTPGQQPQV QTTASQPIPI PPPTSLQAPS QGQPQSQPQV 2520
QSSTQTLSSG QTLNQVTVLS PSCPQPQPQV IAVPQLQQVQ VLSQIQSQVV AQIQAQQSGV 2580
PQQIKLQLPI QVQQNSAAQT QSVVTVQAAS VQEQLQRVQQ LRDQQQKKKQ QIETEREHTL 2640
QASNQSEIIQ KQVVMKHNAV IEHLKQKKTM TPAEREENQR MIVCNQVMKY ILDKIDKEEK 2700
QAAKKRKREE SVEQKRSKQN ASKLSALLFK HKEQLKAEIL RKRALLDKEL QIQVQEELKR 2760
DLKMKREREM AQAVQANAAS VPTPSVPAPV PAPAPAAPPA PPRSPPPSTH SLPPAGHPTA 2820
PLPVTSQKRK REEEKDSKSK KKKMISTTSK EAKKDTRLYC ICKTPYDESK FYIGCDRCQN 2880
WYHGRCVGIL QSEADLIDEY VCPQCQSTED AMTVLTPLTE KDYEGLKRVL RSLQAHKMAW 2940
PFLEPVDPND APDYYGVIKE PMDLATMEER IQKRYYEKLT EFVADMTKIF DNCRYYNPRD 3000
TPFYQCAEVL ESFFVQKLKG FKASRSHNNK LQSTAP 3036 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0001892; P:embryonic placenta development; IMP:MGI.
 GO:0007492; P:endoderm development; IMP:MGI. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR004022; DDT_dom.
 IPR018500; DDT_dom_subgr.
 IPR018501; DDT_dom_superfamily.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF02791; DDT
 PF00628; PHD 
SMART
 SM00297; BROMO
 SM00571; DDT
 SM00249; PHD 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50827; DDT
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS
 PR00503; BROMODOMAIN.