| Tag | Content |
|---|
| CPLM ID | CPLM-015875 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Activating transcription factor 7-interacting protein 1 |
Protein Synonyms/Alias | ATFa-associated modulator; mAM; MBD1-containing chromatin-associated factor 1 |
Gene Name | Atf7ip |
Gene Synonyms/Alias | Mcaf1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 657 | DKTLAELKTRVEKIE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). May have ATPase activity. |
Sequence Annotation | DOMAIN 1054 1143 Fibronectin type-III 1.
DOMAIN 1193 1297 Fibronectin type-III 2.
REGION 596 851 Interaction with SETDB1 (By similarity).
REGION 1001 1011 Interaction with SUMO (By similarity).
REGION 1190 1306 Interaction with MBD1 (By similarity).
MOTIF 587 605 Nuclear localization signal.
MOD_RES 112 112 Phosphoserine (By similarity).
MOD_RES 124 124 Phosphothreonine (By similarity).
MOD_RES 358 358 Phosphoserine.
MOD_RES 514 514 Phosphoserine.
MOD_RES 533 533 Phosphoserine.
MOD_RES 593 593 Phosphoserine (By similarity).
MOD_RES 707 707 Phosphoserine (By similarity).
MOD_RES 933 933 Phosphoserine (By similarity). |
Keyword | Activator; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1306 AA |
Protein Sequence | MDSVEEPQKK VFKARKTMRA SDRQQLDAVH RVKGELLRAD GKLLNGSHEN GDLDPTSPLE 60
NTDCIQDREE VNGIDGICFQ SEESTTEWKE TPCMPNVAVK NKQEDLNSEA LSPSITCDLS 120
SRVTTEPGSG SPASDNPGCG TPVSDNPASD NPASDNPASD NPDSGDLAAG ELATTVQATG 180
DSACEEPPSS DPSSSDPTSS EPSSSEPTCS EPISGDPVSE EAASHDLVSG DSTCSEPVSG 240
EPVSHEAASS EPATSEPASD EPVARVVAAC ELAPGESALD DCAPSGDSQS DEPPSSEDSL 300
PRSVCSGLAS GELTPGELSV EPATDTVKPS SSAVCEAGPD PDKTEPSSNN SDDCPGKSED 360
DEHLDQIQSK DSCDEGNKVN SNVVEKEEPL ETHSAIICSD LPPENTTKIA EDPIAEPALE 420
EEAISSSMEV DQSEKDEHKS PAEPVAAVSE DPAEEDKEDT VVDNTDSMET DEIIPILEKL 480
APTEDELSCF SKASLLPVET SQDLEDKMEG SFGSPSKQES SENLPKEAFL VLSDEEDLSC 540
GKDESEAVAQ SKMSTPEGEK SEKDGKAEEE ERVPAEEQPP VRNEFSRRKR SKSEDMDSVE 600
SKRRRYMDEE YEAEFQVKIT AKGDINQKLQ KVIQWLLQEK LCALQCAVFD KTLAELKTRV 660
EKIECNKRHK AVLTELQAKI ARLTKRFGAA KDDLKKRQES PPNPPISPGK PANDTNSNNN 720
MTYRNAGTVR QLLESKRNVS EGPPPSFQTP VNTVSSASHA TSTAVVSSQP KLQTSATSGS 780
LPAAPLLPAP STATVVATTQ VPSGTPQPTI SLQPLPVILH VPVAVTSQPQ LLQSHPGTLV 840
TNQPSGNVEF ISVQSQPTVS GLTKNPVSLP PLPNPTKPNI PSVPSPSSIQ RNSSTTAAPL 900
GTTLAVQAVP TAHSIVQATR TSLPTVGPSG LYSSSSSRGP IQMKIPISTF SPPSSAEQNS 960
SATPRIVTEN QTNKTVDSSI NKKAADSTSQ SGKASSSDSS GVIDLTMDDE ESGTTQDPKK 1020
ISPPSSSTVS TSQPMSRPLQ PILPAPPLQP SGVPTSGPSQ ATIHVLPTAP TTVNVTHRPV 1080
TQVTTRLPVP RAPANHQVVY TTLPAPTTQA PLRGTVMQAP AVRQVNPQNS VTVRVPQTTT 1140
YVVNNGLTLG SAGPQLTVHH RPPQVHNEPP RPLHPAPLPE APQPQRLPPE AASTSLPQKP 1200
HLKLARVQSQ NGIVLSWSVL EVDRSCATVD SYHLYAYHEE PSATVPSQWK KIGEVKALPL 1260
PMACTLTQFV SGSKYYFAVR AKDIYGRFGP FCDPQSTDVI SSSQNS 1306 |
Gene Ontology | GO:0005667; C:transcription factor complex; IDA:MGI. GO:0016887; F:ATPase activity; IDA:MGI. GO:0003714; F:transcription corepressor activity; IDA:MGI. GO:0006306; P:DNA methylation; ISS:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0045898; P:regulation of RNA polymerase II transcriptional preinitiation complex assembly; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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