UniProt Accession

 LTOR3_HUMAN; Q9UHA4; B2R4A1; J3KMX4; Q9H364 

Genbank Protein ID

 AF201947; AF130115; AL544981; AK311755; AP001962; CH471057; BC026245 

Genbank Nucleotide ID

 AAF17239.1; AAG35540.1; BAG34698.1; EAX06112.1; AAH26245.1 

Protein Name

 Ragulator complex protein LAMTOR3 

Protein Synonyms/Alias

 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1 

Gene Name

 LAMTOR3 

Gene Synonyms/Alias

 MAP2K1IP1; MAPKSP1; PRO2783 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	LATDQGSKLGLSKNK	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. 

Sequence Annotation

 REGION 57 70 Required for interaction with LAMTOR2 (By  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Endosome; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0071986; C:Ragulator complex; IDA:UniProtKB.
 GO:0034613; P:cellular protein localization; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB. 

Interpro

 IPR015019; LAMTOR3. 

Pfam

 PF08923; MAPKK1_Int 

SMART

  

PROSITE

  

PRINTS