UniProt Accession

 RLME_RHOPA; Q6N7Q9 

Genbank Protein ID

 BX572600 

Genbank Nucleotide ID

 CAE27638.1 

Protein Name

 Ribosomal RNA large subunit methyltransferase E 

Protein Synonyms/Alias

 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase 

Gene Name

 rlmE 

Gene Synonyms/Alias

 ftsJ; rrmJ; RPA2197 

Created Date

 July 27, 2013 

Organism

 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 

NCBI Taxa ID

 258594 

Lysine Modification

Position	Peptide	Type	References
85	WSQVAAKKVGAADGR	acetylation	[1]
210	VKPAASRKDSSERYL	acetylation	[1]

Reference

 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 

Functional Description

 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity). 

Sequence Annotation

 ACT_SITE 179 179 Proton acceptor (By similarity).
 BINDING 76 76 S-adenosyl-L-methionine; via amide
 BINDING 78 78 S-adenosyl-L-methionine; via amide
 BINDING 99 99 S-adenosyl-L-methionine (By similarity).
 BINDING 115 115 S-adenosyl-L-methionine (By similarity).
 BINDING 139 139 S-adenosyl-L-methionine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Methyltransferase; rRNA processing; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008650; F:rRNA (uridine-2'-O-)-methyltransferase activity; IEA:HAMAP. 

Interpro

 IPR015507; rRNA-MeTfrase_E.
 IPR002877; rRNA_MeTrfase_FtsJ_dom. 

Pfam

 PF01728; FtsJ 

SMART

  

PROSITE

  

PRINTS