UniProt Accession

 NDK_THET8; Q5SLV5 

Genbank Protein ID

 AP008226 

Genbank Nucleotide ID

 BAD70011.1 

Protein Name

 Nucleoside diphosphate kinase 

Protein Synonyms/Alias

 NDK; NDP kinase; Nucleoside-2-P kinase 

Gene Name

 ndk 

Gene Synonyms/Alias

 TTHA0188 

Created Date

 July 27, 2013 

Organism

 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 

NCBI Taxa ID

 300852 

Lysine Modification

Position	Peptide	Type	References
55	HYAEHREKPFFPGLV	acetylation	[1]

Reference

 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. 

Sequence Annotation

 ACT_SITE 115 115 Pros-phosphohistidine intermediate (By
 BINDING 9 9 ATP.
 BINDING 57 57 ATP.
 BINDING 85 85 ATP.
 BINDING 91 91 ATP.
 BINDING 102 102 ATP.
 BINDING 112 112 ATP.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:HAMAP.
 GO:0006241; P:CTP biosynthetic process; IEA:HAMAP.
 GO:0006183; P:GTP biosynthetic process; IEA:HAMAP.
 GO:0006228; P:UTP biosynthetic process; IEA:HAMAP. 

Interpro

 IPR001564; Nucleoside_diP_kinase. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.