CPLM-003835

Genbank Nucleotide ID

T-cell-specific surface glycoprotein CD28

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
138	TIIHVKGKHLCPSPL	ubiquitination	[1]
204	RRPGPTRKHYQPYAP	ubiquitination	[1, 2, 3]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

DOMAIN 28 137 Ig-like V-type.
MOD_RES 189 189 Phosphoserine.
MOD_RES 191 191 Phosphotyrosine.
MOD_RES 209 209 Phosphotyrosine.
CARBOHYD 37 37 N-linked (GlcNAc...).
CARBOHYD 71 71 N-linked (GlcNAc...).
CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
CARBOHYD 105 105 N-linked (GlcNAc...).
CARBOHYD 129 129 N-linked (GlcNAc...).
DISULFID 40 112
DISULFID 66 86

3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO:0005887; C:integral to plasma membrane; TAS:UniProtKB.
GO:0015026; F:coreceptor activity; TAS:UniProtKB.
GO:0042802; F:identical protein binding; NAS:UniProtKB.
GO:0005070; F:SH3/SH2 adaptor activity; IDA:UniProtKB.
GO:0042089; P:cytokine biosynthetic process; TAS:UniProtKB.
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
GO:0006959; P:humoral immune response; TAS:UniProtKB.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0045060; P:negative thymic T cell selection; IEA:Compara.
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IEA:Compara.
GO:0002863; P:positive regulation of inflammatory response to antigenic stimulus; IEA:Compara.
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IDA:UniProtKB.
GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Compara.
GO:0045840; P:positive regulation of mitosis; IDA:UniProtKB.
GO:0042102; P:positive regulation of T cell proliferation; IDA:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
GO:0045727; P:positive regulation of translation; NAS:UniProtKB.
GO:0045070; P:positive regulation of viral genome replication; NAS:UniProtKB.
GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
GO:0045066; P:regulatory T cell differentiation; IDA:BHF-UCL.
GO:0031295; P:T cell costimulation; TAS:Reactome.
GO:0016032; P:viral reproduction; TAS:Reactome.

IPR008093; CD28.
IPR013783; Ig-like_fold.
IPR013106; Ig_V-set.

PR01717; CD28ANTIGEN.