UniProt Accession

 NQO1_RAT; P05982; Q63478 

Genbank Protein ID

 J02608; J02679; M36660; J02640; M31805; M31801; M31802; M31804; M33039; M33038; BC083542; X17464 

Genbank Nucleotide ID

 AAA41716.1; AAA41715.1; AAA39829.1; AAA41988.1; AAA41989.1; AAA41989.1; AAA41989.1; AAA41989.1; AAA41990.1; AAA41990.1; AAH83542.1 

Protein Name

 NAD(P)H dehydrogenase [quinone] 1 

Protein Synonyms/Alias

 Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1 

Gene Name

 Nqo1 

Gene Synonyms/Alias

 Nmor1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
31	EAAVEALKKKGWEVV	acetylation	[1]
61	NDITGEPKDSENFQY	acetylation	[1]
77	VESSLAYKEGRLSPD	acetylation	[1]
90	PDIVAEQKKLEAADL	acetylation	[1]
249	EVQEEQKKNKFGLSV	acetylation	[1]
251	QEEQKKNKFGLSVGH	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. 

Sequence Annotation

 NP_BIND 18 19 FAD.
 NP_BIND 104 107 FAD.
 NP_BIND 148 151 FAD.
 REGION 126 128 Substrate binding (By similarity).
 BINDING 12 12 FAD.
 BINDING 67 67 FAD.
 BINDING 156 156 FAD.
 BINDING 201 201 FAD.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IDA:RGD.
 GO:0004784; F:superoxide dismutase activity; IMP:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0043086; P:negative regulation of catalytic activity; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0006979; P:response to oxidative stress; IEP:RGD.
 GO:0006801; P:superoxide metabolic process; IMP:RGD. 

Interpro

 IPR003680; Flavodoxin_fold. 

Pfam

 PF02525; Flavodoxin_2 

SMART

  

PROSITE

  

PRINTS