CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diacylglycerol O-acyltransferase 2 
Protein Synonyms/Alias
 Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2 
Gene Name
 Dgat2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
264KNRKGFVKLALRHGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). 
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Endoplasmic reticulum; Glycerol metabolism; Lipid biosynthesis; Lipid droplet; Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MKTLIAAYSG VLRGERRAEA ARSENKNKGS ALSREGSGRW GTGSSILSAL QDIFSVTWLN 60
RSKVEKQLQV ISVLQWVLSF LVLGVACSVI LMYTFCTDCW LIAVLYFTWL AFDWNTPKKG 120
GRRSQWVRNW AVWRYFRDYF PIQLVKTHNL LTTRNYIFGY HPHGIMGLGA FCNFSTEATE 180
VSKKFPGIRP YLATLAGNFR MPVLREYLMS GGICPVNRDT IDYLLSKNGS GNAIIIVVGG 240
AAESLSSMPG KNAVTLKNRK GFVKLALRHG ADLVPTYSFG ENEVYKQVIF EEGSWGRWVQ 300
KKFQKYIGFA PCIFHGRGLF SSDTWGLVPY SKPITTVVGE PITVPKLEHP TQKDIDLYHA 360
MYMEALVKLF DNHKTKFGLP ETEVLEVN 388 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:BHF-UCL.
 GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0003846; F:2-acylglycerol O-acyltransferase activity; IDA:MGI.
 GO:0004144; F:diacylglycerol O-acyltransferase activity; ISS:UniProtKB.
 GO:0050252; F:retinol O-fatty-acyltransferase activity; IEA:EC.
 GO:0071400; P:cellular response to oleic acid; IMP:BHF-UCL.
 GO:0035356; P:cellular triglyceride homeostasis; IMP:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IMP:BHF-UCL.
 GO:0046339; P:diacylglycerol metabolic process; IDA:BHF-UCL.
 GO:0060613; P:fat pad development; IMP:BHF-UCL.
 GO:0055089; P:fatty acid homeostasis; IGI:BHF-UCL.
 GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
 GO:0019915; P:lipid storage; IMP:BHF-UCL.
 GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IDA:BHF-UCL.
 GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.
 GO:0019432; P:triglyceride biosynthetic process; ISS:UniProtKB. 
Interpro
 IPR007130; DAGAT. 
Pfam
 PF03982; DAGAT 
SMART
  
PROSITE
  
PRINTS