| Tag | Content |
|---|
| CPLM ID | CPLM-011985 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TNF receptor-associated factor 1 |
Protein Synonyms/Alias | Epstein-Barr virus-induced protein 6 |
Gene Name | TRAF1 |
Gene Synonyms/Alias | EBI6 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 185 | LQHFMKEKLLAELEG | ubiquitination | [1] | | 193 | LLAELEGKLRVFENI | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. |
Sequence Annotation | DOMAIN 266 412 MATH.
MOD_RES 69 69 Phosphoserine (By similarity).
MOD_RES 146 146 Phosphoserine (By similarity).
CROSSLNK 185 185 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 193 193 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 416 AA |
Protein Sequence | MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE DQICPKCRGE 60
DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS PQSVQEHEVT SQTSHLNLLL 120
GFMKQWKARL GCGLESGPMA LEQNLSDLQL QAAVEVAGDL EVDCYRAPCS ESQEELALQH 180
FMKEKLLAEL EGKLRVFENI VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ 240
QTLAQKDQAL GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK 300
YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL DQNNREHAID 360
AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY VKDDTMFLKC IVETST 416 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB. GO:0006461; P:protein complex assembly; TAS:ProtInc. GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IDA:UniProtKB. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |