CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033502
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Structural maintenance of chromosomes protein 6 
Protein Synonyms/Alias
  
Gene Name
 SMC6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133TNRGSSLKGFVKDGQubiquitination[1]
137SSLKGFVKDGQNSADubiquitination[1, 2]
227SKQFLQSKNEGDKYKubiquitination[1]
246ATQLEQMKEDYSYIMubiquitination[2]
256YSYIMETKERTKEQIubiquitination[1, 2, 3, 4]
294IAGLSTMKTNLESLKubiquitination[3]
301KTNLESLKHEMAWAVubiquitination[1]
684SSENTRPKFLSRDVDubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 740 AA 
Protein Sequence
MAKRKEENFS SPKNAKRPRQ EELEDFDKDG DEDECKGTTL TAAEVGIIES IHLKNFMCHS 60
MLGPFKFGSN VNFVVGNNGS WSAVVRSRLN ATSASQVQAI LLFQPCGKSA VLTALIVGLG 120
GRAVATNRGS SLKGFVKDGQ NSADISITLR NRGDDAFKAS VYGNSILIQQ HISIDGSRSY 180
KLKSATGSVV STRKEELIAI LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT 240
QLEQMKEDYS YIMETKERTK EQIHQGEERL TELKRQCVEK EERFQSIAGL STMKTNLESL 300
KHEMAWAVVN EIEKQLNAIR DNIKIGEDRA ARLDRKMEEQ QVRLNEAEQK YKDIQDKLEK 360
ISEETNARAP ECMALKADVV AKKRAYNEAE VLYNRSLNEY KALKKDDEQL CKRIEELKKS 420
TDQSLEPERL ERQKKISWLK ERVKAFQNQE NSVNQEIEQF QQAIEKDKEE HGKIKREELD 480
VKHALSYNQR QLKELKDSKT DRLKRFGPNV PALLEAIDDA YRQGHFTYKP VGPLGACIHL 540
RDPELALAIE SCLKGLLQAY CCHNHADERV LQALMKRFYL PGTSRPPIIV SEFRNEIYDV 600
RHRAAYHPDF PTVLTALEID NAVVANSLID MRGIETVLLI KNNSVARAVM QSQKPPKNCR 660
EAFTADGDQV FAGRYYSSEN TRPKFLSRDV DSEISDLENE VENKTAQILN LQQHLSALEK 720
DIKHNEELLK RCQLHYKELK 740 
Gene Ontology
 GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR027132; SMC6. 
Pfam
  
SMART
  
PROSITE
  
PRINTS