| Tag | Content |
|---|
| CPLM ID | CPLM-024398 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DENN domain-containing protein 3 |
Protein Synonyms/Alias | |
Gene Name | DENND3 |
Gene Synonyms/Alias | KIAA0870 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 339 | FNSEEFLKTRAPGDH | ubiquitination | [1] | | 575 | LISEILDKPHEASKL | ubiquitination | [1] | | 581 | DKPHEASKLDDHVKK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. |
Sequence Annotation | DOMAIN 6 83 UDENN.
DOMAIN 105 291 DENN.
DOMAIN 354 417 dDENN.
REPEAT 984 1026 WD 1.
REPEAT 1073 1113 WD 2.
REPEAT 1165 1198 WD 3. |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Polymorphism; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1198 AA |
Protein Sequence | MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL TLPQLCFPGG VCVATEPKED 60
CVHFLVLTDV CGNRTYGVVA QYYRPLHDEY CFYNGKTHRE CPGCFVPFAV CVVSRFPYYN 120
SLKDCLSCLL ALLKPCKDFE VDSHIKDFAA KLSLIPSPPP GPLHLVFNMK SLQIVLPARA 180
DPESPILDLD LHLPLLCFRP EKVLQILTCI LTEQRIVFFS SDWALLTLVT ECFMAYLYPL 240
QWQHPFVPIL SDQMLDFVMA PTSFLMGCHL DHFEEVSKEA DGLVLINIDH GSITYSKSTD 300
DNVDIPDVPL LAAQTFIQRD VKNHLNYEHR VFNSEEFLKT RAPGDHQFYK QVLDTYMFHS 360
FLKARLNRRM DAFAQMDLDT QSEEDRINGM LLSPRRPTVE KRASRKSSHL HVTHRRMVVS 420
MPNLQDIAMP ELAPRNSSLR LTDTAGCRGS SAVLNVTPKS PYTFKIPEIH FPLESKCVQA 480
YHAHFVSMLS EAMCFLAPDN SLLLARYLYL RGLVYLMQGQ LLNALLDFQN LYKTDIRIFP 540
TDLVKRTVES MSAPEWEGAE QAPELMRLIS EILDKPHEAS KLDDHVKKFK LPKKHMQLGD 600
FMKRVQESGI VKDASIIHRL FEALTVGQEK QIDPETFKDF YNCWKETEAE AQEVSLPWLV 660
MEHLDKNECV CKLSSSVKTN LGVGKIAMTQ KRLFLLTEGR PGYLEISTFR NIEEVRRTTT 720
TFLLRRIPTL KIRVASKKEV FEANLKTECD LWHLMVKEMW AGKKLADDHK DPHYVQQALT 780
NVLLMDAVVG TLQSPGAIYA ASKLSYFDKM SNEMPMTLPE TTLETLKHKI NPSAGEAFPQ 840
AVDVLLYTPG HLDPAEKVED AHPKLWCALS EGKVTVFNAS SWTIHQHSFK VGTAKVNCMV 900
MADQNQVWVG SEDSVIYIIN VHSMSCNKQL TAHCSSVTDL IVQDGQEAPS NVYSCSMDGM 960
VLVWNVSTLQ VTSRFQLPRG GLTSIRLHGG RLWCCTGNSI MVMKMNGSLH QELKIEENFK 1020
DTSTSFLAFQ LLPEEEQLWA ACAGRSEVYI WSLKDLAQPP QRVPLEDCSE INCMIRVKKQ 1080
VWVGSRGLGQ GTPKGKIYVI DAERKTVEKE LVAHMDTVRT LCSAEDRYVL SGSGREEGKV 1140
AIWKGE 1146 |
Gene Ontology | GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:0044257; P:cellular protein catabolic process; ISS:UniProtKB. GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |