CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein 60, mitochondrial 
Protein Synonyms/Alias
 60 kDa chaperonin; Protein Cpn60 
Gene Name
 HSP60 
Gene Synonyms/Alias
 CaO19.717; CaO19.8336 
Created Date
 July 27, 2013 
Organism
 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 
NCBI Taxa ID
 237561 
Lysine Modification
Position
Peptide
Type
References
324FTEELDIKPENATIEsumoylation[1]
Reference
 [1] Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans.
 Leach MD, Stead DA, Argo E, Brown AJ.
 Mol Biol Cell. 2011 Mar 1;22(5):687-702. [PMID: 21209325] 
Functional Description
 May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Mitochondrion; Nucleotide-binding; Reference proteome; Stress response; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 566 AA 
Protein Sequence
MLRVNSKSSI KTFVRHLSHK ELKFGVEGRA ALLKGVNTLA DAVSVTLGPK GRNVLIEQQF 60
GAPKITKDGV TVAKAITLED KFEDLGAKLL QEVASKTNES AGDGTTSATV LGRSIFTESV 120
KNVAAGCNPM DLRRGSQAAV EAVIEFLQKN KKEITTSEEI AQVATISANG DKHIGDLLAN 180
AMEKVGKEGV ITVKEGKTLE DELEVTEGMK FDRGFISPYF ITNTKTGKVE FENPLILLSE 240
KKISSIQDIL PSLELSNQTR RPLLIIAEDV DGEALAACIL NKLRGQVQVC AVKAPGFGDN 300
RKNTLGDIAI LSGGTVFTEE LDIKPENATI EQLGSAGAVT ITKEDTVLLN GEGSKDNLEA 360
RCEQIRSVIA DVHTTEYEKE KLQERLAKLS GGVAVIKVGG ASEVEVGEKK DRYEDALNAT 420
RAAVEEGILP GGGTALIKAT KILDEVKEKA VNFDQKLGVD TIRAAITKPA KRIIENAGEE 480
GAVIVGKIYD EPEFNKGYDS QKGEFTDMIA AGIIDPFKVV KNGLVDASGV ASLLATTECA 540
IVDAPQPKGS PAAPPAPGMG GMPGMF 566 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0035690; P:cellular response to drug; IMP:CGD.
 GO:0034605; P:cellular response to heat; IMP:CGD.
 GO:0042026; P:protein refolding; IEA:InterPro. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.