UniProt Accession

 NADC_HUMAN; Q15274; Q53XW7; Q96G22; Q9BSG6 

Genbank Protein ID

 D78177; BT007231; BC005060; BC010033; BC018910 

Genbank Nucleotide ID

 BAA11242.1; AAP35895.1; AAH05060.1; AAH10033.1; AAH18910.1 

Protein Name

 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 

Protein Synonyms/Alias

 Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase 

Gene Name

 QPRT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
139	GHVAGTRKTTPGFRL	ubiquitination	[1]
149	PGFRLVEKYGLLVGG	ubiquitination	[1, 2]
171	LGGLVMVKDNHVVAA	ubiquitination	[1]
183	VAAGGVEKAVRAARQ	ubiquitination	[1, 3, 4, 5, 6]
288	FSLKLFAKEVAPVPK	ubiquitination	[1, 5]
295	KEVAPVPKIH*****	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in the catabolism of quinolinic acid (QA). 

Sequence Annotation

 REGION 137 139 Substrate binding.
 REGION 248 250 Substrate binding (By similarity).
 REGION 269 271 Substrate binding (By similarity).
 BINDING 102 102 Substrate.
 BINDING 161 161 Substrate.
 BINDING 171 171 Substrate.
 BINDING 201 201 Substrate (By similarity).
 BINDING 222 222 Substrate (By similarity).  

Keyword

 3D-structure; Complete proteome; Glycosyltransferase; Polymorphism; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019674; P:NAD metabolic process; TAS:Reactome.
 GO:0051259; P:protein oligomerization; IDA:UniProtKB.
 GO:0034213; P:quinolinate catabolic process; IDA:UniProtKB.
 GO:0006767; P:water-soluble vitamin metabolic process; TAS:Reactome. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR004393; NadC.
 IPR027277; NadC/ModD.
 IPR002638; Quinolinate_PRibosylTrfase_C.
 IPR022412; Quinolinate_PRibosylTrfase_N. 

Pfam

 PF01729; QRPTase_C
 PF02749; QRPTase_N 

SMART

  

PROSITE

  

PRINTS