UniProt Accession

 D3Z6C3_MOUSE; D3Z6C3 

Genbank Protein ID

 CT571277 

Genbank Nucleotide ID

  

Protein Name

 40S ribosomal protein S3a 

Protein Synonyms/Alias

  

Gene Name

 Rps3a2 

Gene Synonyms/Alias

 Gm10119; Rps3a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	GKKGAKKKVVDPFSK	acetylation	[1]
27	KVVDPFSKKDWYDVK	acetylation	[2]
34	KKDWYDVKAPAMFNI	acetylation	[1]
34	KKDWYDVKAPAMFNI	ubiquitination	[3]
46	FNIRNIGKTLVTRTQ	acetylation	[1, 4]
46	FNIRNIGKTLVTRTQ	succinylation	[4]
46	FNIRNIGKTLVTRTQ	ubiquitination	[3]
56	VTRTQGTKIASDGLK	acetylation	[4]
56	VTRTQGTKIASDGLK	succinylation	[4]
63	KIASDGLKGRVFEVS	acetylation	[4]
63	KIASDGLKGRVFEVS	succinylation	[4]
85	EVAFRKFKLITEDVQ	acetylation	[1]
94	ITEDVQGKNCLTNFH	acetylation	[1, 2]
94	ITEDVQGKNCLTNFH	ubiquitination	[3]
109	GMDLTRDKMCSMVKK	acetylation	[4]
109	GMDLTRDKMCSMVKK	ubiquitination	[3]
144	LFCVGFTKKRNNQIR	acetylation	[2, 5]
144	LFCVGFTKKRNNQIR	phosphoglycerylation	[6]
144	LFCVGFTKKRNNQIR	ubiquitination	[3]
167	QVRQIRKKMMEIMTR	acetylation	[4]
167	QVRQIRKKMMEIMTR	succinylation	[4]
167	QVRQIRKKMMEIMTR	ubiquitination	[3]
182	EVQTNDLKEVVNKLI	acetylation	[2]
182	EVQTNDLKEVVNKLI	ubiquitination	[3]
187	DLKEVVNKLIPDSIG	acetylation	[1, 4]
187	DLKEVVNKLIPDSIG	succinylation	[4]
195	LIPDSIGKDIEKACQ	acetylation	[2]
199	SIGKDIEKACQSIYP	acetylation	[1]
240	GEGGSSGKAAGDETG	ubiquitination	[3]
249	AGDETGAKVERADGY	acetylation	[2]
249	AGDETGAKVERADGY	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [6] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

 May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Differentiation; Nucleus; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IEA:HAMAP.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003735; F:structural constituent of ribosome; IEA:HAMAP.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR027500; Ribosomal_S1/3_euk.
 IPR001593; Ribosomal_S3Ae.
 IPR018281; Ribosomal_S3Ae_CS. 

Pfam

 PF01015; Ribosomal_S3Ae 

SMART

  

PROSITE

 PS01191; RIBOSOMAL_S3AE 

PRINTS