UniProt Accession

 IMDH_BACSU; P21879 

Genbank Protein ID

 X55669; D26185; AL009126 

Genbank Nucleotide ID

 CAA39204.1; BAA05245.1; CAB11785.1 

Protein Name

 Inosine-5'-monophosphate dehydrogenase 

Protein Synonyms/Alias

 IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 

Gene Name

 guaB 

Gene Synonyms/Alias

 gnaB; BSU00090 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
159	KISDVMTKEELVTAS	acetylation	[1]
202	LKGLITIKDIEKVIE	acetylation	[1]
206	ITIKDIEKVIEFPNS	acetylation	[1]
215	IEFPNSSKDIHGRLI	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). 

Sequence Annotation

 DOMAIN 95 153 CBS 1.
 DOMAIN 157 214 CBS 2.
 NP_BIND 301 303 NAD (By similarity).
 REGION 341 343 IMP binding (By similarity).
 REGION 364 365 IMP binding (By similarity).
 REGION 388 392 IMP binding (By similarity).
 ACT_SITE 308 308 Thioimidate intermediate (By similarity).
 METAL 303 303 Potassium; via carbonyl oxygen (By
 METAL 305 305 Potassium; via carbonyl oxygen (By
 METAL 308 308 Potassium; via carbonyl oxygen (By
 METAL 470 470 Potassium; via carbonyl oxygen; shared
 METAL 471 471 Potassium; via carbonyl oxygen; shared
 METAL 472 472 Potassium; via carbonyl oxygen; shared
 BINDING 251 251 NAD (By similarity).
 BINDING 306 306 IMP (By similarity).
 BINDING 416 416 IMP (By similarity).  

Keyword

 CBS domain; Complete proteome; Direct protein sequencing; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0003938; F:IMP dehydrogenase activity; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:HAMAP.
 GO:0006177; P:GMP biosynthetic process; IEA:HAMAP. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR000644; Cysta_beta_synth_core.
 IPR005990; IMP_DH.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 

Pfam

 PF00571; CBS
 PF00478; IMPDH 

SMART

 SM00116; CBS 

PROSITE

 PS51371; CBS
 PS00487; IMP_DH_GMP_RED 

PRINTS