| Tag | Content |
|---|
| CPLM ID | CPLM-008097 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arachidonate 5-lipoxygenase |
Protein Synonyms/Alias | 5-LO; 5-lipoxygenase |
Gene Name | Alox5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 456 | LCFPEAIKARGMDST | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. |
Sequence Annotation | DOMAIN 2 118 PLAT.
DOMAIN 119 674 Lipoxygenase.
METAL 17 17 Calcium 1; via carbonyl oxygen;
METAL 18 18 Calcium 2; via carbonyl oxygen;
METAL 19 19 Calcium 2; structural (By similarity).
METAL 44 44 Calcium 2; structural (By similarity).
METAL 45 45 Calcium 2; via carbonyl oxygen;
METAL 47 47 Calcium 2; structural (By similarity).
METAL 79 79 Calcium 1; via carbonyl oxygen;
METAL 80 80 Calcium 1; via carbonyl oxygen;
METAL 368 368 Iron; catalytic (By similarity).
METAL 373 373 Iron; catalytic (By similarity).
METAL 551 551 Iron; catalytic (By similarity).
METAL 555 555 Iron; catalytic (By similarity).
METAL 674 674 Iron; via carboxylate; catalytic (By
MOD_RES 272 272 Phosphoserine (By similarity).
MOD_RES 524 524 Phosphoserine (By similarity). |
Keyword | Calcium; Complete proteome; Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Membrane; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 674 AA |
Protein Sequence | MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGA VDSYDVTVDE 60
ELGEIYLVKI EKRKYWLHDD WYLKYITLKT PHGDYIEFPC YRWITGEGEI VLRDGRAKLA 120
RDDQIHILKQ HRRKELEARQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 180
NYSKAMENLF INRFMHMFQS SWHDFADFEK IFVKISNTIS ERVKNHWQED LMFGYQFLNG 240
CNPVLIKRCT ALPPKLPVTT EMVECSLERQ LSLEQEVQEG NIFIVDYELL DGIDANKTDP 300
CTHQFLAAPI CLLYKNLANK IVPIAIQLNQ TPGESNPIFL PTDSKYDWLL AKIWVRSSDF 360
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPLFKLLVAH VRFTIAINTK AREQLICEYG 420
LFDKANATGG GGHVQMVQRA VQDLTYSSLC FPEAIKARGM DSTEDIPFYF YRDDGLLVWE 480
AIQSFTMEVV SIYYENDQVV EEDQELQDFV KDVYVYGMRG KKASGFPKSI KSREKLSEYL 540
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 600
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMIRFRK NLEAIVSVIA ERNKNKKLPY 660
YYLSPDRIPN SVAI 674 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005641; C:nuclear envelope lumen; ISS:UniProtKB. GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell. GO:0031965; C:nuclear membrane; ISS:UniProtKB. GO:0004051; F:arachidonate 5-lipoxygenase activity; IEA:EC. GO:0005506; F:iron ion binding; ISS:UniProtKB. GO:0016165; F:lipoxygenase activity; IEA:InterPro. GO:0019370; P:leukotriene biosynthetic process; IDA:MGI. GO:0002540; P:leukotriene production involved in inflammatory response; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |