CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ALDH6A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104SVLSRQQKEIAKLITmethylation[1]
116LITLEQGKTLADAEGacetylation[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 522 AA 
Protein Sequence
MAALLAAAAV RARILQVSSK VKSSPTWYSA SSFSSSVPTV KLFIGGKFVE SKSDKWIDIH 60
NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQKEIAKLI TLEQGKTLAD 120
AEGDVFRGLQ VVEHACSVTS LMMGETMPSI TKDMDLYSYR LPLGVCAGIA PFNFPAMIPL 180
WMFPMAMVCG NTFLMKPSER VPGATMLLAK LLQDSGAPDG TLNIIHGQHE AVNFICDHPD 240
IKAISFVGSN KAGEYIFERG SRHGKRVQAN MGAKNHGVVM PDANKENTLN QLVGAAFGAA 300
GQRCMALSTA VLVGEAKKWL PELVEHAKNL RVNAGDQPGA DLGPLITPQA KERVCNLIDS 360
GTKEGASILL DGRKIKVKGY ENGNFVGPTI ISNVKPNMTC YKEEIFGPVL VVLETETLDE 420
AIQIVNNNPY GNGTAIFTTN GATARKYAHL VDVGQVGVNV PIPVPLPMFS FTGSRSSFRG 480
DTNFYGKQGI QFYTQLKTIT SQWKEEDATL SSPAVVMPTM GR 522 
Gene Ontology
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; IEA:InterPro. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS 
PRINTS