CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 8-A 
Protein Synonyms/Alias
  
Gene Name
 Abca8a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
485IRIRNLTKDYIQKSKubiquitination[1]
506DLTLDVYKGQITAILubiquitination[1]
544WVTIHNNKLSEMTDLubiquitination[1]
584LRLFAKIKGIQAHEVubiquitination[1]
620QNLSGGQKRKLTFGIubiquitination[1]
658HRVWNFLKERRADRVubiquitination[1]
692FISKGKLKCAGSSLFubiquitination[1]
735KQHIPDSKLSAESEGubiquitination[1]
743LSAESEGKLSYILPLubiquitination[1]
755LPLERTNKFPDLYRDubiquitination[1]
791VFLKLEGKSSIDQSDubiquitination[1]
1328LGHNGAGKSTSIKMIubiquitination[1]
1340KMITGETKPSAGQVLubiquitination[1]
1405ERLADALKLQDQLKSubiquitination[1]
1415DQLKSPVKTLSEGVKubiquitination[1]
1519YLLEMKVKTPSQVEPubiquitination[1]
1566PLSQAFFKLETVKQSubiquitination[1]
1611EELDPSVKWKLLPQEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 ATP-dependent lipophilic drug transporter (By similarity). 
Sequence Annotation
 DOMAIN 478 713 ABC transporter 1.
 DOMAIN 1284 1517 ABC transporter 2.
 NP_BIND 514 521 ATP 1 (Potential).
 NP_BIND 1322 1329 ATP 2 (Potential).
 CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).
 CARBOHYD 482 482 N-linked (GlcNAc...) (Potential).
 CARBOHYD 967 967 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1620 AA 
Protein Sequence
MVKREINVCQ QTWALLCKNL LRKKRLKRDT FLEFLYTALI LLSLILFLQL HEVYDFSSLP 60
DVDLGRIDSF NDSTFMIVYT PITPTTQRIM DRVSLVSYMT GRKILASPNE ENMTELISMR 120
FSDVVGVIFT NAYSYNLKFI KGARIPTIKE HQDHTAHCHS YGEIIYCGLS EFWRDGFVAL 180
QAAINAAIIE VTTNHSVMEE MMSLTGKYIK IDSFVGQEGT TTDCFLFFCI IRFSPLTYYI 240
SAGVTRERKK MKGLMAVMGL RDSAFWLSWG LLYGVIVFVV TLLSTTIVKL VQFVFLTGFM 300
VIFSLFFFYG LSLISLSFLM SVLLKKSFLT DLVVFLLTVS CGSLGFTALY RYLPVSLEWL 360
LSLLSPFAFM LGMVQLLRLD YDVNSNADPM GNPNEVIGTI FMLFFDGVFY LLLTFYFEKV 420
LPSKSFHDKT YWHACKSHFF LIDYSFYIRT ALDNETDYEF SDDSFEPVSM EFHGKEAIRI 480
RNLTKDYIQK SKRTEALKDL TLDVYKGQIT AILGHSGAGK STLLNVLSGL CVPTKGWVTI 540
HNNKLSEMTD LENISKLTGV CPQCNVQFDF LTVRENLRLF AKIKGIQAHE VDNEVQRVLL 600
ELDMKNTQNI LVQNLSGGQK RKLTFGIAIL GDPQIFLLDE PTAGLDPFSR HRVWNFLKER 660
RADRVVLFST QFMDEADILA DRKVFISKGK LKCAGSSLFL KKKWGIGYHL SLQLSETCVH 720
ERITSLVKQH IPDSKLSAES EGKLSYILPL ERTNKFPDLY RDLERSPDLG IENYGVSITT 780
LTEVFLKLEG KSSIDQSDIG MTEDVQAGGA RSPERFAEVE QLVSLLNGRC KMKGGMALWW 840
QQLCAVTRLR FLKLKHERKS IVILILVLGI GLLHILSANI YRMVRQSDYC WELAPHMYFL 900
TPGQQPQPPL TNLLIVNKTG AKIDDFIHSL EQQNIALEVD AFGTRNGTED SQYNGAIILS 960
GDEKNYNFTL ACNTKRLNCF PVLVDIVSNG LLGLFAPSAH IQTDRSTFPE ENDHRKFDYL 1020
AYFFLWVLLM ACVPPYISMT SIDDYKNRAQ FQLWISGLSP SAYWFGQALF EVPVYCALIL 1080
SIFIAFYASA PPESKFTVGD LFIQILYVGG YAMSVIFMTY VISFIYRKGR KNSGLWSLCF 1140
YIVSFFSMCF MLIDYFRDIS LFVLIALVPP ATLGGCTLLH FENREFSEII FEPEREYSYL 1200
FFLAPLLHFA IFVVILRCME RKFGMKTMRT DPVFRISPRS DRVFNNPEDP DGEDEDVSQE 1260
RVWTANALTS ADFQEKPAII ASCLRKEYKG KKKCFVLKSK KKIATRNISF CVRKGEVVGL 1320
LGHNGAGKST SIKMITGETK PSAGQVLLKG SSTGDTPGFL GYCPQENALW LNLTVREHLE 1380
IFAAIKGMRK SDANVAIERL ADALKLQDQL KSPVKTLSEG VKRKLCFVLS ILGNPSVVLL 1440
DEPSTGMDPE GQQQMWQAIQ ATFSNTERGA LLTTHYMAEA EAVCDRVAIM VSGRLRCIGS 1500
IQHLKSKFGK EYLLEMKVKT PSQVEPLNTE IMRLFPQAAR QERYSSLMVY KLPREDVQPL 1560
SQAFFKLETV KQSFDLEEYS LSQSTLEQVF LELSKEQELD GFEEELDPSV KWKLLPQEEA 1620 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS