CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-alpha-acetyltransferase 25, NatB auxiliary subunit 
Protein Synonyms/Alias
 Mitochondrial distribution and morphology protein 20; N-terminal acetyltransferase B complex subunit MDM20; NatB complex subunit MDM20; N-terminal acetyltransferase B complex subunit NAA25 
Gene Name
 Naa25 
Gene Synonyms/Alias
 Mdm20 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
244AMYKKLSKWPECNALubiquitination[1]
327VRGPHLAKLELIRRLubiquitination[1]
357ELMFQYFKKFGDKPCubiquitination[1]
586EYIIQAYKYGAFEKIubiquitination[1]
747TGKRFIEKEIQYPFLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu (By similarity). May play a role in normal cell-cycle progression (By similarity). 
Sequence Annotation
 REPEAT 11 44 TPR 1.
 REPEAT 45 78 TPR 2.
 REPEAT 79 112 TPR 3.
 REPEAT 114 146 TPR 4.
 MOD_RES 691 691 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 972 AA 
Protein Sequence
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL KAIGLQRTGK 60
QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK LYEAAVKKVP NSEEYHSHLF 120
MAYARVGEYK KMQQAGMALY KIVPKNPYYF WSVMSLIMQS ISARDENLSK TMFLPLAERM 180
VEKMVKEDKI EAEAEVELYY MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK 240
KLSKWPECNA LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WTPPAEGEHS LEGEVHCSAE 300
DAVKFIEDRI TEASQSSRHV RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE LMFQYFKKFG 360
DKPCCFTDLK VFVDLLPAAQ CTQFINQLLG VVPLSTPTED KLALPADIRG LQQHLCVVQL 420
TRLLGLYHSM DKSQKLDVVK ELMLRYQHGL EFGRSCLKTE LQFSDYYCLL AVHVLIDVWR 480
EAGEETAVWQ ALTLLEEGLT HSPSNAQFKL LLVRIYCVLG AFEPVVDLYS SLDAKHIQHD 540
TIGYLLTRYA ASLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR 600
NRLNNSLHFA QVRTERMLLD LLLEANISIS LAESIKSMNL RPEEDDVPWE DLRDNRDLDV 660
FFSWDPKDRN VSEEHKKLSL EEETMWLRIR SLTLRLISGL PSLTHPVEPK NSEKMSENGV 720
SSRIDILRLL LQQLEVAVET GKRFIEKEIQ YPFLGPVPTR MGRFFSSGCC QCQVQSFHLV 780
SDMYELDTSG LEGTVDIQER IENSLASLLE LLKGVFSTCK GDLLEVTDGN VKTQPAVLEN 840
LVFFVETISV ILWVSSYCES VLRPYKLNIQ KKKKKKKETS IIMPPIFTSF QDYVTGLQTV 900
ISNAVDHIKG LEAHLIALRL EELTLEETSI STEERKFSKT VQGKVQSSYL HSLLETGELL 960
RKRLETTKKL KI 972 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. 
Interpro
 IPR019183; N-acetylTrfase_B_cplx_non-cat.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical. 
Pfam
 PF09797; NatB_MDM20 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS