| Tag | Content |
|---|
| CPLM ID | CPLM-015290 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine nucleotide-binding protein-like 3-like protein |
Protein Synonyms/Alias | |
Gene Name | Gnl3l |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 159 | VLRAEGNKKLVLVLN | acetylation | [1] | | 160 | LRAEGNKKLVLVLNK | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). |
Sequence Annotation | DOMAIN 258 314 G.
NP_BIND 166 169 GTP (Potential).
NP_BIND 253 260 GTP (Potential).
NP_BIND 297 300 GTP (Potential).
REGION 9 28 Required for nucleolar localization (By |
Keyword | Coiled coil; Complete proteome; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 577 AA |
Protein Sequence | MMKIRHKNKK PGKGSKGCKK PARQNGKKVT SRPSSAPQIV HGNDHASREA ELKKKRVEEM 60
REKQQVAREQ ERQRHRTMES YCQDVLKRQQ EFEQKEEVLQ ELNMFPQLDD EATRKAYYKE 120
FRKVVEYSDV ILEVLDARDP LGCRCFQMEE TVLRAEGNKK LVLVLNKIDL VPKEIVEKWL 180
EYLLNELPTV AFKASTQHHQ VKNLTRCKVP VDQASESLLK SRACFGAENL MRVLGNYCRL 240
GEVRGHIRVG VVGLPNVGKS SLINSLKRSR ACSVGAVPGV TKFMQEVYLD KFIRLLDAPG 300
IVPGPNSEVG TILRNCIHVQ KLADPVTPVE TILQRCNLEE ISSYYGVSGF QTTEHFLTAV 360
AHRLGKKKKG GVYSQEQAAK AVLADWVSGK ISFYTLPPPT HTLPTHLSAE IVKEMTEVFD 420
IEDTEHANED TMECLAVGES DELLGDMDPQ EMEVRWLHSP LVKIADAIEN RSTVYKIGNL 480
TGYCTKPNRN QMGWPKRNVD HHCPQNNRVV EVSSVDRRPM LQRILETDPL QQGQALASAL 540
KNKKKLQKRS DKIATKLSDS MMSMLDLSGN SDDCAGD 577 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |